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dc.contributor.authorMuhi, S
dc.contributor.authorTayler, N
dc.contributor.authorHoang, T
dc.contributor.authorBallard, SA
dc.contributor.authorGraham, M
dc.contributor.authorRojek, A
dc.contributor.authorKwong, JC
dc.contributor.authorTrubiano, JA
dc.contributor.authorSmibert, O
dc.contributor.authorDrewett, G
dc.contributor.authorJames, F
dc.contributor.authorGardiner, E
dc.contributor.authorChea, S
dc.contributor.authorIsles, N
dc.contributor.authorSait, M
dc.contributor.authorPasricha, S
dc.contributor.authorTaiaroa, G
dc.contributor.authorMcAuley, J
dc.contributor.authorWilliams, E
dc.contributor.authorGibney, KB
dc.contributor.authorStinear, TP
dc.contributor.authorBond, K
dc.contributor.authorLewin, SR
dc.contributor.authorPutland, M
dc.contributor.authorHowden, BP
dc.contributor.authorWilliamson, DA
dc.date.accessioned2021-05-11T01:05:50Z
dc.date.available2021-05-11T01:05:50Z
dc.date.issued2021-04-01
dc.identifierpii: S2666-6065(21)00024-9
dc.identifier.citationMuhi, S., Tayler, N., Hoang, T., Ballard, S. A., Graham, M., Rojek, A., Kwong, J. C., Trubiano, J. A., Smibert, O., Drewett, G., James, F., Gardiner, E., Chea, S., Isles, N., Sait, M., Pasricha, S., Taiaroa, G., McAuley, J., Williams, E. ,... Williamson, D. A. (2021). Multi-site assessment of rapid, point-of-care antigen testing for the diagnosis of SARS-CoV-2 infection in a low-prevalence setting: A validation and implementation study. LANCET REGIONAL HEALTH-WESTERN PACIFIC, 9, https://doi.org/10.1016/j.lanwpc.2021.100115.
dc.identifier.issn2666-6065
dc.identifier.urihttp://hdl.handle.net/11343/273839
dc.description.abstractBackground: In Australia, COVID-19 diagnosis relies on RT-PCR testing which is relatively costly and time-consuming. To date, few studies have assessed the performance and implementation of rapid antigen-based SARS-CoV-2 testing in a setting with a low prevalence of COVID-19 infections, such as Australia. Methods: This study recruited participants presenting for COVID-19 testing at three Melbourne metropolitan hospitals during a period of low COVID-19 prevalence. The Abbott PanBioTM COVID-19 Ag point-of-care test was performed alongside RT-PCR. In addition, participants with COVID-19 notified to the Victorian Government were invited to provide additional swabs to aid validation. Implementation challenges were also documented. Findings: The specificity of the Abbott PanBioTM COVID-19 Ag test was 99.96% (95% CI 99.73 - 100%). Sensitivity amongst participants with RT-PCR-confirmed infection was dependent upon the duration of symptoms reported, ranging from 77.3% (duration 1 to 33 days) to 100% in those within seven days of symptom onset. A range of implementation challenges were identified which may inform future COVID-19 testing strategies in a low prevalence setting. Interpretation: Given the high specificity, antigen-based tests may be most useful in rapidly triaging public health and hospital resources while expediting confirmatory RT-PCR testing. Considering the limitations in test sensitivity and the potential for rapid transmission in susceptible populations, particularly in hospital settings, careful consideration is required for implementation of antigen testing in a low prevalence setting. Funding: This work was funded by the Victorian Department of Health and Human Services. The funder was not involved in data analysis or manuscript preparation.
dc.languageEnglish
dc.publisherELSEVIER
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleMulti-site assessment of rapid, point-of-care antigen testing for the diagnosis of SARS-CoV-2 infection in a low-prevalence setting: A validation and implementation study
dc.typeJournal Article
dc.identifier.doi10.1016/j.lanwpc.2021.100115
melbourne.affiliation.departmentDoherty Institute
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentInfectious Diseases
melbourne.affiliation.departmentMedical Education
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleLANCET REGIONAL HEALTH-WESTERN PACIFIC
melbourne.source.volume9
melbourne.source.pages100115-
melbourne.identifier.nhmrc1105905
melbourne.identifier.nhmrc1120816
melbourne.identifier.nhmrc1142613
melbourne.identifier.nhmrc1174555
melbourne.identifier.nhmrc1191321
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1504900
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076656
melbourne.contributor.authorHowden, Benjamin
melbourne.contributor.authorMcAuley, Julie
melbourne.contributor.authorStinear, Timothy
melbourne.contributor.authorPasricha, Shivani
melbourne.contributor.authorWilliamson, Deborah
melbourne.contributor.authorGibney, Katherine
melbourne.contributor.authorTaiaroa, George
melbourne.contributor.authorGraham, Maryza
melbourne.contributor.authorPutland, Mark
melbourne.contributor.authorMuhi, Stephen
melbourne.contributor.authorLewin, Sharon
dc.identifier.eissn2666-6065
melbourne.identifier.fundernameidNHMRC, 1105905
melbourne.identifier.fundernameidNHMRC, 1120816
melbourne.identifier.fundernameidNHMRC, 1142613
melbourne.identifier.fundernameidNHMRC, 1174555
melbourne.identifier.fundernameidNHMRC, 1191321
melbourne.accessrightsOpen Access


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