Automated radiosynthesis of [Ga-68]Ga-PSMA-11 and [Lu-177]Lu-PSMA-617 on the iPHASE MultiSyn module for clinical applications
AuthorWichmann, CW; Ackermann, U; Poniger, S; Young, K; Nguyen, B; Chan, G; Sachinidis, J; Scott, AM
Source TitleJournal of Labelled Compounds and Radiopharmaceuticals
University of Melbourne Author/sWichmann, Christian; Scott, Andrew; Ackermann, Uwe; Nguyen, Benjamin; SACHINIDIS, JOHN
AffiliationMedicine and Radiology
School of Chemistry
Document TypeJournal Article
CitationsWichmann, C. W., Ackermann, U., Poniger, S., Young, K., Nguyen, B., Chan, G., Sachinidis, J. & Scott, A. M. (2020). Automated radiosynthesis of [Ga-68]Ga-PSMA-11 and [Lu-177]Lu-PSMA-617 on the iPHASE MultiSyn module for clinical applications. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 64 (3), pp.140-146. https://doi.org/10.1002/jlcr.3889.
Access StatusOpen Access
Prostate-specific membrane antigen (PSMA)-targeted imaging and therapy of prostate cancer using theranostic pairs is rapidly changing clinical practice. To facilitate clinical trials, fully automated procedures for the radiosyntheses of [68 Ga]Ga-PSMA-11 and [177 Lu]Lu-PSMA-617 were developed from commercially available precursors using the cassette based iPHASE MultiSyn module. Formulated and sterile radiopharmaceuticals were obtained in 76 ± 3% (n = 20) and 91 ± 4% (n = 15) radiochemical yields after 17 and 20 min, respectively. Radiochemical purity was always >95% and molar activities exceeded 792 ± 100 and 88 ± 6 GBq/μmol, respectively. Quality control showed conformity with all relevant release criteria and radiopharmaceuticals were used in the clinic.
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