Sir Peter MacCallum Department of Oncology - Research Publications
Now showing items 1-10 of 211
Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice
PIK3CA, the gene encoding the p110 alpha catalytic subunit of PI3K (phosphoinositide 3-kinase), is mutated in approximately 20% of sporadic CRCs (colorectal cancers), but the role of these mutations in the pathogenesis of ...
Patterns of chemotherapy treatment for women with invasive epithelial ovarian cancer - A population-based study
Objective. Ovarian cancer five-year survival is poor at <40%. In the absence of effective screening or new treatments, ensuring all women receive optimal treatment is one avenue to improve survival. There is little ...
Genomic Aberrations of BRCA1-Mutated Fallopian Tube Carcinomas
(ELSEVIER SCIENCE INC, 2014-06-27)
Intraepithelial carcinomas of the fallopian tube are putative precursors to high-grade serous carcinomas of the ovary and peritoneum. Molecular characterization of these early precursors is limited but could be the key to ...
Combined Anti-CD40 and Anti-IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases
(AMER ASSOC CANCER RESEARCH, 2014-05-27)
Tumor-induced immunosuppression remains one of the major obstacles to many potentially effective cancer therapies and vaccines. Host interleukin (IL)-23 suppresses the immune response during tumor initiation, growth, and ...
Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis
(COMPANY OF BIOLOGISTS LTD, 2014-03-27)
The VEGFC/VEGFR3 signaling pathway is essential for lymphangiogenesis (the formation of lymphatic vessels from preexisting vasculature) during embryonic development, tissue regeneration and tumor progression. The recently ...
Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation
(COMPANY OF BIOLOGISTS LTD, 2013-09-27)
The crucial role the Crumbs and Par polarity complexes play in tight junction integrity has long been established, however very few studies have investigated the role of the Scribble polarity module. Here, we use MCF10A ...
The Role of the Apoptotic Machinery in Tumor Suppression
(COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 2012-11-27)
Multicellular organisms have evolved processes to prevent abnormal proliferation or inappropriate tissue infiltration of cells, and these tumor suppressive mechanisms serve to prevent tissue hyperplasia, tumor development, ...
Targeting Oncogenic Drivers and the Immune System in Melanoma
(AMER SOC CLINICAL ONCOLOGY, 2013-02-27)
Melanoma is one of the most common cancers in Western countries but has defied the trend of reductions in age-adjusted mortality observed in most other cancers in recent years. Biologically, melanoma is characterized by a ...
NLRP3 Suppresses NK Cell-Mediated Responses to Carcinogen-Induced Tumors and Metastases
(AMER ASSOC CANCER RESEARCH, 2012-11-27)
The NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response upon infectious insults or tissue injury and damage. However, the role of the NLRP3 inflammasome in natural ...
The interaction between murine melanoma and the immune system reveals that prolonged responses predispose for autoimmunity
(LANDES BIOSCIENCE, 2013-02-27)
An assessment of antitumor immunity versus autoimmunity as provoked by the specific depletion of FOXP3(+) Tregs is now possible with the development of Foxp3-diphtheria toxin receptor-like transgenic mouse models. We have ...