Adaptive immunity to human coronaviruses is widespread but low in magnitude
Web of Science
AuthorTan, H-X; Lee, WS; Wragg, KM; Nelson, C; Esterbauer, R; Kelly, HG; Amarasena, T; Jones, R; Starkey, G; Wang, BZ; ...
Source TitleClinical & Translational Immunology
University of Melbourne Author/sMackay, Laura; Kent, Stephen; Wheatley, Adam; Esterbauer, Robyn; Juno, Jennifer; Kelly, Hannah; Wragg, Kathleen; Gordon, Claire; Tan, Hyon Xhi; Jones, Robert
AffiliationMicrobiology and Immunology
Surgery (Austin & Northern Health)
Document TypeJournal Article
CitationsTan, H. -X., Lee, W. S., Wragg, K. M., Nelson, C., Esterbauer, R., Kelly, H. G., Amarasena, T., Jones, R., Starkey, G., Wang, B. Z., Yoshino, O., Tiang, T., Grayson, M. L., Opdam, H., D'Costa, R., Vago, A., Mackay, L. K., Gordon, C. L., Wheatley, A. K. ,... Juno, J. A. (2021). Adaptive immunity to human coronaviruses is widespread but low in magnitude. CLINICAL & TRANSLATIONAL IMMUNOLOGY, 10 (3), https://doi.org/10.1002/cti2.1264.
Access StatusOpen Access
NHMRC Grant codeNHMRC/1149990
Objectives: Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little is known about hCoV-specific T-cell memory in adults. Methods: We quantified CD4 T-cell and antibody responses to hCoV spike antigens in 42 SARS-CoV-2-uninfected individuals. Antigen-specific memory T cells and circulating T follicular helper (cTFH) cells were identified using an activation-induced marker assay and characterised for memory phenotype and chemokine receptor expression. Results: T-cell responses were widespread within conventional memory and cTFH compartments but did not correlate with IgG titres. SARS-CoV-2 cross-reactive T cells were observed in 48% of participants and correlated with HKU1 memory. hCoV-specific T cells exhibited a CCR6+ central memory phenotype in the blood, but were enriched for frequency and CXCR3 expression in human lung-draining lymph nodes. Conclusion: Overall, hCoV-specific humoral and cellular memory are independently maintained, with a shared phenotype existing among coronavirus-specific CD4 T cells. This understanding of endemic coronavirus immunity provides insight into the homeostatic maintenance of immune responses that are likely to be critical components of protection against SARS-CoV-2.
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