Show simple item record

dc.contributor.authorTan, H-X
dc.contributor.authorLee, WS
dc.contributor.authorWragg, KM
dc.contributor.authorNelson, C
dc.contributor.authorEsterbauer, R
dc.contributor.authorKelly, HG
dc.contributor.authorAmarasena, T
dc.contributor.authorJones, R
dc.contributor.authorStarkey, G
dc.contributor.authorWang, BZ
dc.contributor.authorYoshino, O
dc.contributor.authorTiang, T
dc.contributor.authorGrayson, ML
dc.contributor.authorOpdam, H
dc.contributor.authorD'Costa, R
dc.contributor.authorVago, A
dc.contributor.authorMackay, LK
dc.contributor.authorGordon, CL
dc.contributor.authorWheatley, AK
dc.contributor.authorKent, SJ
dc.contributor.authorJuno, JA
dc.date.accessioned2021-05-11T02:15:07Z
dc.date.available2021-05-11T02:15:07Z
dc.date.issued2021-01-01
dc.identifierpii: CTI21264
dc.identifier.citationTan, H. -X., Lee, W. S., Wragg, K. M., Nelson, C., Esterbauer, R., Kelly, H. G., Amarasena, T., Jones, R., Starkey, G., Wang, B. Z., Yoshino, O., Tiang, T., Grayson, M. L., Opdam, H., D'Costa, R., Vago, A., Mackay, L. K., Gordon, C. L., Wheatley, A. K. ,... Juno, J. A. (2021). Adaptive immunity to human coronaviruses is widespread but low in magnitude. CLINICAL & TRANSLATIONAL IMMUNOLOGY, 10 (3), https://doi.org/10.1002/cti2.1264.
dc.identifier.issn2050-0068
dc.identifier.urihttp://hdl.handle.net/11343/274074
dc.description.abstractObjectives: Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little is known about hCoV-specific T-cell memory in adults. Methods: We quantified CD4 T-cell and antibody responses to hCoV spike antigens in 42 SARS-CoV-2-uninfected individuals. Antigen-specific memory T cells and circulating T follicular helper (cTFH) cells were identified using an activation-induced marker assay and characterised for memory phenotype and chemokine receptor expression. Results: T-cell responses were widespread within conventional memory and cTFH compartments but did not correlate with IgG titres. SARS-CoV-2 cross-reactive T cells were observed in 48% of participants and correlated with HKU1 memory. hCoV-specific T cells exhibited a CCR6+ central memory phenotype in the blood, but were enriched for frequency and CXCR3 expression in human lung-draining lymph nodes. Conclusion: Overall, hCoV-specific humoral and cellular memory are independently maintained, with a shared phenotype existing among coronavirus-specific CD4 T cells. This understanding of endemic coronavirus immunity provides insight into the homeostatic maintenance of immune responses that are likely to be critical components of protection against SARS-CoV-2.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleAdaptive immunity to human coronaviruses is widespread but low in magnitude
dc.typeJournal Article
dc.identifier.doi10.1002/cti2.1264
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentSurgery (Austin & Northern Health)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleClinical & Translational Immunology
melbourne.source.volume10
melbourne.source.issue3
melbourne.identifier.nhmrc1149990
dc.rights.licenseCC BY
melbourne.elementsid1505328
melbourne.contributor.authorMackay, Laura
melbourne.contributor.authorKent, Stephen
melbourne.contributor.authorWheatley, Adam
melbourne.contributor.authorEsterbauer, Robyn
melbourne.contributor.authorJuno, Jennifer
melbourne.contributor.authorKelly, Hannah
melbourne.contributor.authorWragg, Kathleen
melbourne.contributor.authorGordon, Claire
melbourne.contributor.authorTan, Hyon Xhi
melbourne.contributor.authorJones, Robert
dc.identifier.eissn2050-0068
melbourne.identifier.fundernameidNHMRC, 1149990
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record