Electrophysiologic effects following acute intracochlear direct current stimulation of the guinea pig cochlea
AuthorTykocinski, M.; Shepherd, R. K.; Clark, Graeme M.
Source TitleAnnals of Otology, Rhinology & Laryngology
Document TypeJournal Article
CitationsTykocinski, M., Shepherd, R. K., & Clark, G. M. (1995). Electrophysiologic effects following acute intracochlear direct current stimulation of the guinea pig cochlea. Annals of Otology, Rhinology & Laryngology, 104(suppl.166), 68-71.
Access StatusOpen Access
This is a publisher’s version of an article published in Annals of Otology, Rhinology & Laryngology published by Annals Publishing Company. This version is reproduced with permission from Annals Publishing Company. http://www.annals.com/
Auditory brain stem responses to both acoustic (auditory brain stem response [ABR]) and electrical (electrically evoked auditory brain stem response [EABR]) stimuli, as well as the frequency-specific compound action potential (CAP), were recorded before and periodically following continuous intracochlear DC stimulation (2, 7, and 12 µA) for 2 hours in normal-hearing guinea pigs, by means of a banded intracochlear electrode array. Click-evoked ABR, frequency-specific CAP, and the EABR input-output function remained generally unchanged following stimulation at 2 µA DC. However, following stimulation at 7and 12 µA, a significant decrement of the amplitude of the click-evoked ABR, frequency-specific CAP, and electrophonic component of the EABR was observed, while there was an increase in the amplitude of the EABR, associated with direct electrical stimulation of the auditory nerve.
Keywordsauditory brain stem response; acoustic stimuli; electrical stimuli; guinea pig; cochlea; electrophonic component
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- Graeme Clark Collection