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dc.contributor.authorBruce, Ian C.en_US
dc.contributor.authorWhite, Mark W.en_US
dc.contributor.authorIrlicht, Laurence S.en_US
dc.contributor.authorO'Leary, Stephen J.en_US
dc.contributor.authorDynes, Scotten_US
dc.contributor.authorJavel, Ericen_US
dc.contributor.authorClark, Graeme M.en_US
dc.date.accessioned2014-05-21T20:30:06Z
dc.date.available2014-05-21T20:30:06Z
dc.date.issued1999en_US
dc.identifier.citationBruce, I. C., White, M. W., Irlicht, L. S., O'Leary, S. J., Dynes, S., Javel, E., et al. (1999). A stochastic model of the electrically stimulated auditory nerve: single-pulse response. IEEE Transactions on Biomedical Engineering, June, 26(6), 617-629.en_US
dc.identifier.urihttp://hdl.handle.net/11343/27515
dc.descriptionCopyright © 1999 IEEE. Reprinted from IEEE Transactions on Biomedical Engineering, 46(6).en_US
dc.descriptionThis material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of The University of Melbourne's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org.en_US
dc.descriptionBy choosing to view this document, you agree to all provisions of the copyright laws protecting it.en_US
dc.description.abstractMost models of neural response to electrical stimulation, such as the Hodgkin-Huxley equations, are deterministic, despite significant physiological evidence for the existence of stochastic activity. For instance, the range of discharge probabilities measured in response to single electrical pulses cannot be explained at all by deterministic models. Furthermore, there is growing evidence that the stochastic component of auditory nerve response to electrical stimulation may be fundamental to functionally significant physiological and psychophysical phenomena. In this paper we present a simple and computationally efficient stochastic model of single-fiber response to single biphasic electrical pulses, based on a deterministic threshold model of action potential generation. Comparisons with physiological data from cat auditory nerve fibers are made, and it is shown that the stochastic model predicts discharge probabilities measured in response to single biphasic pulses more accurately than does the equivalent deterministic model. In addition, physiological data show an increase in stochastic activity with increasing pulse width of anodic/cathodic biphasic pulses, a phenomenon not present for monophasic stimuli. These and other data from the auditory nerve are then used to develop a population model of the total auditory nerve, where each fiber is described by the single-fiber model.en_US
dc.relation.ispartofScientific publications, vol.11, 1998-1999, no.1107en_US
dc.subjectotolaryngologyen_US
dc.subjectauditory nerveen_US
dc.subjectcochlear implanten_US
dc.subjectfunctional electrical stimulationen_US
dc.subjectpopulation responseen_US
dc.subjectsensory prosthesisen_US
dc.subjectsingle-pulse responseen_US
dc.subjectstochastic threshold modelen_US
dc.titleA stochastic model of the electrically stimulated auditory nerve: single-pulse responseen_US
dc.typeJournal Articleen_US
melbourne.source.titleIEEE Transactions on Biomedical Engineeringen_US
melbourne.source.monthJuneen_US
melbourne.source.volume46en_US
melbourne.source.issue6en_US
melbourne.source.pages617-629en_US
melbourne.elementsidNA
melbourne.contributor.authorClark, Graeme
melbourne.contributor.authorO'Leary, Stephen
melbourne.accessrightsOpen Access


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