Synergy between TGF-ß3 and NT-3 to promote the survival of spiral ganglia neurones in vitro
AuthorMarzella, P. L.; Clark, Graeme M.; Shepherd, R. K.; Bartlett, P. F.; Kilpatrick, T. J.
Source TitleNeuroscience Letters
University of Melbourne Author/sClark, Graeme; MARZELLA, PHILLIP; Shepherd, Robert; Kilpatrick, Trevor
Document TypeJournal Article
CitationsMarzella, P. L., Clark, G. M., Shepherd, R. K., Bartlett, P. F., & Kilpatrick, T. J. (1998). Synergy between TGF-ß3 and NT-3 to promote the survival of spiral ganglia neurones in vitro. Neuroscience Letters, 240, 77-80.
Access StatusThis item is currently not available from this repository
Publisher’s permission requested and denied.
Transforming growth factor-βs (TGF-βs) have been implicated in normal inner ear development and in promoting neuronal survival. Early rat post-natal spiral ganglion cells (SGC) in dissociated cell culture were used as a model of auditory innervation to test the trophic factors TGF-βs and neurotrophin-3 (NT-3) for their ability, individually or in combination, to promote neuronal survival. The findings from this study suggest that TGF-βs supports neuronal survival in a concentration-dependent manner. Moreover TGF-βs and NT-3-potentiated spiral ganglion neuronal survival in a synergistic fashion.
Keywordsotolaryngology; auditory neurones; pharmacological therapy; cytokine; neurotrophin; neuronal degeneration; neurotrophic effects
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References
- Graeme Clark Collection