Synergy between TGF-ß3 and NT-3 to promote the survival of spiral ganglia neurones in vitro

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    Author
    Marzella, P. L.; Clark, Graeme M.; Shepherd, R. K.; Bartlett, P. F.; Kilpatrick, T. J.
    Date
    1998
    Source Title
    Neuroscience Letters
    University of Melbourne Author/s
    Clark, Graeme; MARZELLA, PHILLIP; Shepherd, Robert; Kilpatrick, Trevor
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    Document Type
    Journal Article
    Citations
    Marzella, P. L., Clark, G. M., Shepherd, R. K., Bartlett, P. F., & Kilpatrick, T. J. (1998). Synergy between TGF-ß3 and NT-3 to promote the survival of spiral ganglia neurones in vitro. Neuroscience Letters, 240, 77-80.
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    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/27520
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    Publisher’s permission requested and denied.
    Abstract
    Transforming growth factor-βs (TGF-βs) have been implicated in normal inner ear development and in promoting neuronal survival. Early rat post-natal spiral ganglion cells (SGC) in dissociated cell culture were used as a model of auditory innervation to test the trophic factors TGF-βs and neurotrophin-3 (NT-3) for their ability, individually or in combination, to promote neuronal survival. The findings from this study suggest that TGF-βs supports neuronal survival in a concentration-dependent manner. Moreover TGF-βs and NT-3-potentiated spiral ganglion neuronal survival in a synergistic fashion.
    Keywords
    otolaryngology; auditory neurones; pharmacological therapy; cytokine; neurotrophin; neuronal degeneration; neurotrophic effects

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