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dc.contributor.authorMarzella, P. L.en_US
dc.contributor.authorClark, Graeme M.en_US
dc.contributor.authorShepherd, R. K.en_US
dc.contributor.authorBartlett, P. F.en_US
dc.contributor.authorKilpatrick, T. J.en_US
dc.identifier.citationMarzella, P. L., Clark, G. M., Shepherd, R. K., Bartlett, P. F., & Kilpatrick, T. J. (1998). Synergy between TGF-ß3 and NT-3 to promote the survival of spiral ganglia neurones in vitro. Neuroscience Letters, 240, 77-80.en_US
dc.descriptionPublisher’s permission requested and denied.en_US
dc.description.abstractTransforming growth factor-βs (TGF-βs) have been implicated in normal inner ear development and in promoting neuronal survival. Early rat post-natal spiral ganglion cells (SGC) in dissociated cell culture were used as a model of auditory innervation to test the trophic factors TGF-βs and neurotrophin-3 (NT-3) for their ability, individually or in combination, to promote neuronal survival. The findings from this study suggest that TGF-βs supports neuronal survival in a concentration-dependent manner. Moreover TGF-βs and NT-3-potentiated spiral ganglion neuronal survival in a synergistic fashion.en_US
dc.relation.ispartofScientific publications, vol.11, 1998-1999, no.1125en_US
dc.subjectauditory neuronesen_US
dc.subjectpharmacological therapyen_US
dc.subjectneuronal degenerationen_US
dc.subjectneurotrophic effectsen_US
dc.titleSynergy between TGF-ß3 and NT-3 to promote the survival of spiral ganglia neurones in vitroen_US
dc.typeJournal Articleen_US
melbourne.source.titleNeuroscience Lettersen_US
melbourne.contributor.authorClark, Graeme
melbourne.contributor.authorMARZELLA, PHILLIP
melbourne.contributor.authorShepherd, Robert
melbourne.contributor.authorKilpatrick, Trevor
melbourne.accessrightsThis item is currently not available from this repository

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