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dc.contributor.authorShepherd, Robert K.en_US
dc.contributor.authorLinahan, N.en_US
dc.contributor.authorXu, J.en_US
dc.contributor.authorClark, Graeme M.en_US
dc.contributor.authorAraki, S.en_US
dc.identifier.citationShepherd, R. K., Linahan, N., Xu, J., Clark, G. M., & Araki, S. (1999). Chronic electrical stimulation of the auditory nerve using non-charge-balanced stimuli. Acta Otolaryngologica, 119, 674-684.en_US
dc.descriptionPublisher’s permission requested and denied.en_US
dc.description.abstractThis study was designed to evaluate the pathophysiological response of the cochlea following long-term intracochlear electrical stimulation using a poorly charge-balanced stimulus regime, leading to direct current (DC) levels >0.1 µA. Four normal-hearing adult cats were bilaterally implanted with scala tympani electrode arrays and unilaterally stimulated for periods up to 2200 h. Stimuli consisted of 50 µs monophasic current pulses presented at 2000 pulses per second (pps) per channel, and resulted in DC levels of 0.4-2.8 µA. Both acoustic and electrical (EABR) evoked potentials were periodically recorded during the stimulation program. Frequency-specific stimuli indicated that an extensive and widespread hearing loss occurred over the 4-24 KHz region in all stimulated cochleae, although the 2 KHz region exhibited thresholds close to normal in some animals, despite long-term implantation and chronic stimulation. Longitudinal EABRs showed a statistically significant increase in threshold for three of the four animals. Histopathological evaluation of the cochleae revealed a highly significant reduction in ganglion cell density in stimulated cochleae compared with their controls. Spiral ganglion cell loss was significantly correlated with the degree of inflammation, duration of electrical stimulation, and the level of DC. In conclusion, the present study highlights the potential for neural damage following stimulation using poorly charge-balanced stimuli.en_US
dc.relation.ispartofScientific publications, vol.11, 1998-1999, no.1144en_US
dc.subjectcochlear implantsen_US
dc.subjectcochlear pathologyen_US
dc.subjectcochlear physiologyen_US
dc.subjectdirect currenten_US
dc.subjectelectrical stimulationen_US
dc.subjectelectrode impedanceen_US
dc.titleChronic electrical stimulation of the auditory nerve using non-charge-balanced stimulien_US
dc.typeJournal Articleen_US
melbourne.source.titleActa Otolaryngologicaen_US
melbourne.contributor.authorClark, Graeme
melbourne.contributor.authorShepherd, Robert
melbourne.contributor.authorXu, Jin
melbourne.accessrightsThis item is currently not available from this repository

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