Show simple item record

dc.contributor.authorPaolini, Antonio G.en_US
dc.contributor.authorClark, Graeme M.en_US
dc.date.accessioned2014-05-21T20:31:12Z
dc.date.available2014-05-21T20:31:12Z
dc.date.issued1999en_US
dc.identifier.citationPaolini, A. G., & Clark, G. M. (1999). Intracellular responses of onset chopper neurons in the ventral cochlear nucleus to tones: evidence for dual-component processing. Journal of Neurophysiology, 81, 2347-2359.en_US
dc.identifier.urihttp://hdl.handle.net/11343/27533
dc.descriptionPublisher’s permission requested and denied.en_US
dc.description.abstractThe ventral cochlear nucleus (VCN) contains a heterogeneous collection of cell types reflecting the multiple processing tasks undertaken by this nucleus. This in vivo study in the rat used intracellular recordings and dye filling to examine membrane potential changes and firing characteristics of onset chopper (OC) neurons to acoustic stimulation (50 ms pure tones, 5 ms r/f time). Stable impalements were made from 15 OC neurons, 7 identified as multipolar cells. Neurons responded to characteristic frequency (CF) tones with sustained depolarization below spike threshold. With increasing stimulus intensity, the depolarization during the initial 10 ms of the response became peaked, and with further increases in intensity the peak became narrower. Onset spikes were generated during this initial depolarization. Tones presented below CF resulted in a broadening of this initial depolarizing component with high stimulus intensities required to initiate onset spikes. This initial component was followed by a sustained depolarizing component lasting until stimulus cessation. The amplitude of the sustained depolarizing component was greatest when frequencies were presented at high intensities below CF resulting in increased action potential firing during this period when compared with comparable high intensities at CF. During the presentation of tones at or above the high-frequency edge of a cell’s response area, hyperpolarization was evident during the sustained component. The presence of hyperpolarization and the differences seen in the level of sustained depolarization during CF and off CF tones suggests that changes in membrane responsiveness between the initial and sustained components may be attributed to polysynaptic inhibitory mechanisms. The dual-component processing resulting from convergent auditory nerve excitation and polysynaptic inhibition enables OC neurons to respond in a unique fashion to intensity and frequency features contained within an acoustic stimulus.en_US
dc.relation.ispartofScientific publications, vol.11, 1998-1999, no.1203en_US
dc.relation.isversionofhttp://tinyurl.com/397ko9zen_US
dc.subjectotolaryngologyen_US
dc.subjectventral cochlear nucleusen_US
dc.subjectVCNen_US
dc.subjectonset chopperen_US
dc.subjectneuronsen_US
dc.subjectcharacteristic frequency tonesen_US
dc.subjectCFen_US
dc.titleIntracellular responses of onset chopper neurons in the ventral cochlear nucleus to tones: evidence for dual-component processingen_US
dc.typeJournal Articleen_US
melbourne.source.titleJournal of Neurophysiologyen_US
melbourne.source.volume81en_US
melbourne.source.pages2347-2359en_US
melbourne.elementsidNA
melbourne.contributor.authorClark, Graeme
melbourne.contributor.authorPaolini, Antonio
melbourne.accessrightsThis item is currently not available from this repository


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record