LIF potentiates the NT-3-mediated survival of spiral ganglia neurones in vitro
AuthorMarzella, P. L.; Clark, Graeme M.; Shepherd, R. K.; Bartlett, P. F.; Kilpatrick, T. J.
University of Melbourne Author/sClark, Graeme; MARZELLA, PHILLIP; Shepherd, Robert; Kilpatrick, Trevor
Document TypeJournal Article
CitationsMarzella, P. L., Clark, G. M., Shepherd, R. K., Bartlett, P. F., & Kilpatrick, T. J. (1997). LIF potentiates the NT-3-mediated survival of spiral ganglia neurones in vitro. NeuroReport, 8, 1641-1644.
Access StatusOpen Access
This is a publisher’s version of an article published in NeuroReport 1997. This version is reproduced with permission of Lippincott Wilkins & Williams.
The survival of auditory neurones depends on the continued supply of trophic factors. Early postnatal spiral ganglion cells (SGC) in a dissociated cell culture were used as a model of auditory innervation to test the trophic factors leukaemia inhibitory factor (LIF) and neurotrophin-3 (NT-3) for their ability, individually or in combination, to promote neuronal survival. The findings suggest that LIF supports neuronal survival in a concentration-dependent manner. Moreover LIF potentiated NT-3-mediated spiral ganglion neuronal survival in a synergistic fashion.
Keywordsauditory neurones; cytokine; neuronal degeneration; neurotrophic effects; neurotrophin; pharmacological therapy
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- Graeme Clark Collection