Centre for Neuroscience - Research Publications
Now showing items 1-10 of 60
Delayed sleep onset in depressed young people
(BIOMED CENTRAL LTD, 2014-02-08)
Background: The circadian abnormality of delayed sleep phase has been suggested to characterise a subgroup of depressed young adults with different risk factors and course of illness. We aim to assess the prevalence and ...
The Effect of Placebo Conditioning on Capsaicin-Evoked Urge to Cough
(AMER COLL CHEST PHYSICIANS, 2012-10-27)
Background: The urge to cough is a clinical symptom of respiratory disease that precedes the motor act of coughing. Although previous studies have shown that cough is particularly susceptible to placebo suppression, it is ...
Blockage of Lysophosphatidic Acid Signaling Improves Spinal Cord Injury Outcomes
(ELSEVIER SCIENCE INC, 2012-09-27)
Evidence suggests a proinflammatory role of lysophosphatidic acid (LPA) in various pathologic abnormalities, including in the central nervous system. Herein, we describe LPA as an important mediator of inflammation after ...
Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell
(American Society for Biochemistry and Molecular Biology, 2014)
Protein aggregation into intracellular inclusions is a key feature of many neurodegenerative disorders. A common theme has emerged that inappropriate selfaggregation of misfolded or mutant polypeptide sequences is detrimental ...
Cocaine-mediated synaptic potentiation is absent in VTA neurons from mGlu5-deficient mice
(Cambridge University Press, 2009)
Drugs of abuse have the ability to instantiate plastic adaptations within the central nervous system, and this property may relate to the development and persistence of addiction. In this context, a single exposure to ...
Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats
(Cambridge University Press, 2008)
Adenosine and glutamate have been implicated as mediators involved in the self-administration of alcohol. In the present study we sought to determine whether adenosine receptors could interact with metabotropic glutamate ...