Delayed neurotrophin treatment supports auditory neuron survival in deaf guinea pigs

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    Author
    Gillespie, Lisa. N.; Clark, Graeme M.; Marzella, Phillip L.
    Date
    2004
    Source Title
    NeuroReport
    University of Melbourne Author/s
    Clark, Graeme; Gillespie, Lisa; MARZELLA, PHILLIP
    Metadata
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    Document Type
    Journal Article
    Citations
    Gillespie, L. N., Clark, G. M., & Marzella, P. L. (2004). Delayed neurotrophin treatment supports auditory neuron survival in deaf guinea pigs. NeuroReport, 15(7), 1121-1125.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/27614
    Description

    This is a publisher’s version of an article published in NeuroReport 2004. This version is reproduced with permission of Lippincott Wilkins & Williams.
    Abstract
    As key factors in the development and maintenance of the auditory system, neurotrophins can prevent auditory neuron degeneration when applied within three to five days of deafening. We tested each of the neurotrophins BDNF, NT-3, NT-4/5 and NGF for their ability to support auditory neuron survival following a two-week period of deafness in guinea pigs, when ~B15% auditory neuron degeneration has already occurred. Although delayed, the treatment with each neurotrophin prevented further degeneration with similar efficacy.
    Keywords
    delayed treatment; neurotrophins; SGN survival

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