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    Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3

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    Author
    Wise, AK; Richardson, R; Hardman, J; Clark, G; O'Leary, S
    Date
    2005-06-27
    Source Title
    JOURNAL OF COMPARATIVE NEUROLOGY
    Publisher
    WILEY
    University of Melbourne Author/s
    O'Leary, Stephen; Clark, Graeme; Wise, Andrew
    Metadata
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    Document Type
    Journal Article
    Citations
    Wise, A. K., Richardson, R., Hardman, J., Clark, G. & O'Leary, S. (2005). Resprouting and survival of guinea pig cochlear neurons in response to the administration of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3. JOURNAL OF COMPARATIVE NEUROLOGY, 487 (2), pp.147-165. https://doi.org/10.1002/cne.20563.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/27625
    DOI
    10.1002/cne.20563
    Description

    Publisher’s permission requested and denied.

    Abstract
    Degeneration of auditory neurons occurs after deafening and is associated with damage to the organ of Corti. The administration of neurotrophins can protect auditory neurons against degeneration if given shortly after deafening. However, it is not known whether the delayed administration of neurotrophins, when significant degeneration has already occurred, will provide similar protection. Furthermore, little is known about the effects of neurotrophins on the peripheral processes of the auditory neurons or whether these neurons can resprout. This study examined the morphological effects on auditory neurons following deafening and the administration of brain-derived neurotrophic factor and neurotrophin-3. Results showed that neurotrophins were effective in preventing death of auditory neurons if administered 5 days after deafening and were also effective in preventing the continued loss of neurons if the administration was delayed by 33 days. The peripheral processes of auditory neurons in cochleae that received neurotrophins were in greater number and had larger diameters compared with the untreated cochleae. Localized regions of resprouting peripheral processes were observed in deafened cochleae and were enhanced in response to neurotrophin treatment, occurring across wider regions of the cochlea. These findings have significant implications for an improvement in the performance of the cochlear implant and for future therapies to restore hearing to the deaf.
    Keywords
    neural regeneration; auditory neurons

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