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dc.contributor.authorWei, Benjamin P. C.en_US
dc.contributor.authorRobins-Browne, Roy M.en_US
dc.contributor.authorShepherd, Robert K.en_US
dc.contributor.authorAZZOPARDI, KRISTYen_US
dc.contributor.authorClark, Graeme M.en_US
dc.contributor.authorO'Leary, Stephen J.en_US
dc.identifier.citationWei, B. P. C., Robins-Browne, R. M., Shepherd, R. K., Azzopardi, K., Clark, G. M., & O'Leary, S. J. (2006). Protective effects of local administration of ciprofloxacin on the risk of pneumococccal meningitis after cochlear implantation. Laryngoscope, 116(12), 2138-2144.en_US
dc.descriptionPublisher’s permission requested and denied.en_US
dc.description.abstractObjectives: To determine whether ciprofloxacin retains its antimicrobial activity after storage with Healon at ambient temperature and at 37°C over 5 weeks and then to establish whether the application of ciprofloxacin/Healon onto scala tympani electrode arrays reduces the risk of meningitis in implanted rats inoculated with S. pneumoniae. Study Design: In vitro laboratory and in vivo animal studies Methods: The antibacterial activity of three concentrations of ciprofloxacin/Healon (7.5, 75, and 750 µg/mL) was examined over 5 weeks at both ambient temperature (23°C) and body temperature (37°C). Thirty-six rats (18 implanted with ciprofloxacin [750 mg/mL]/Healon-coated electrode array and 18 without the coating) were infected with S. pneumoniae 4 weeks after implantation by way of three different routes of infection (hematogenous, middle ear, and inner ear) and observed for the development of meningitis. Results: The antibacterial activity of ciprofloxacin/Healon was maintained over 5 weeks at both 23°C and 37°C. The implanted rats with the ciprofloxacin/Healon-coated electrode array were protected from meningitis when the bacteria were given by way of the hematogenous route (Fisher’s exact test, P = .008) but not when the bacteria were inoculated directly into the middle or inner ear. However, the time to develop meningitis was significantly longer in rats implanted with a coated array, irrespective of the route of inoculation (P < .05, log rank test). Conclusion: Our animal model demonstrated that a ciprofloxacin-coated electrode array can protect healthy implanted rats from meningitis when the route of infection is hematogenous and can delay the onset of meningitis when bacteria are inoculated directly into the middle or inner ear.en_US
dc.relation.ispartofScientific publications, vol.14, 2005-2007, no.1692en_US
dc.subjectsodium hyaluronateen_US
dc.subjectpneumococcal meningitisen_US
dc.subjectcochlear implantationen_US
dc.subjectStreptococcus pneumoniaeen_US
dc.titleProtective effects of local administration of ciprofloxacin on the risk of pneumococccal meningitis after cochlear implantationen_US
dc.typeJournal Articleen_US
melbourne.source.titleThe Laryngoscopeen_US
melbourne.contributor.authorWei, Benjamin
melbourne.contributor.authorClark, Graeme
melbourne.contributor.authorO'Leary, Stephen
melbourne.contributor.authorShepherd, Robert
melbourne.contributor.authorRobins-Browne, Roy
melbourne.contributor.authorAZZOPARDI, KRISTY
melbourne.accessrightsThis item is currently not available from this repository

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