Assessment of the protective effect of pneumococcal vaccination in preventing meningitis after cochlear implantation
AuthorWei, Benjamin P. C.; Robins-Browne, Roy M.; Shepherd, Robert K.; AZZOPARDI, KRISTY; Clark, Graeme M.; O'Leary, Stephen J.
Source TitleArchives of Otolaryngology - Head and Neck Surgery
University of Melbourne Author/sWei, Benjamin; Clark, Graeme; O'Leary, Stephen; Shepherd, Robert; Robins-Browne, Roy; AZZOPARDI, KRISTY
Document TypeJournal Article
CitationsWei, B. P. C., Robins-Browne, R. M., Shepherd, R. K., Azzopardi, K., Clark, G. M., & O'Leary, S. J. (2007). Assessment of the protective effect of pneumococcal vaccination in preventing meningitis after cochlear implantation. Archives of Otolaryngology - Head and Neck Surgery, 133(10), 987-994.
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Objectives: To examine if a 23-valent pneumococcal capsular polysaccharide vaccine (PPV23) reduces the risk of meningitis in healthy rats after cochlear implantation. Design: Interventional animal study. Interventions: Thirty-six rats (18 immunized and 18 unimmunized) received cochlear implantations and were then infected with Streptococcus pneumoniae via 3 different routes (hematogenous, middle ear, and inner ear) in numbers sufficient to induce meningitis. Results: The rats with implants that received PPV23 were protected from meningitis when the bacteria were delivered via the hematogenous and middle-ear routes (Fisher exact test P<.05). However, the protective effect of the vaccine in the rats with implants was only moderate when the bacteria were inoculated directly into the inner ear. Conclusions: Our animal model clearly demonstrates that immunization can protect healthy rats with a cochlear implant from meningitis caused by a vaccine-covered serotype. This finding supports the notion that all current and future implant recipients should be vaccinated against S pneumoniae.
Keywordscochlear implants; otolaryngology; otology
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