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dc.contributor.authorWei, Benjamin P. C.en_US
dc.contributor.authorRobins-Browne, Roy M.en_US
dc.contributor.authorShepherd, Robert K.en_US
dc.contributor.authorAZZOPARDI, KRISTYen_US
dc.contributor.authorClark, Graeme M.en_US
dc.contributor.authorO'Leary, Stephen J.en_US
dc.identifier.citationWei, B. P. C., Robins-Browne, R. M., Shepherd, R. K., Azzopardi, K., Clark, G. M., & O'Leary, S. J. (2007). Assessment of the protective effect of pneumococcal vaccination in preventing meningitis after cochlear implantation. Archives of Otolaryngology - Head and Neck Surgery, 133(10), 987-994.en_US
dc.descriptionPublisher’s permission requested and denied.en_US
dc.description.abstractObjectives: To examine if a 23-valent pneumococcal capsular polysaccharide vaccine (PPV23) reduces the risk of meningitis in healthy rats after cochlear implantation. Design: Interventional animal study. Interventions: Thirty-six rats (18 immunized and 18 unimmunized) received cochlear implantations and were then infected with Streptococcus pneumoniae via 3 different routes (hematogenous, middle ear, and inner ear) in numbers sufficient to induce meningitis. Results: The rats with implants that received PPV23 were protected from meningitis when the bacteria were delivered via the hematogenous and middle-ear routes (Fisher exact test P<.05). However, the protective effect of the vaccine in the rats with implants was only moderate when the bacteria were inoculated directly into the inner ear. Conclusions: Our animal model clearly demonstrates that immunization can protect healthy rats with a cochlear implant from meningitis caused by a vaccine-covered serotype. This finding supports the notion that all current and future implant recipients should be vaccinated against S pneumoniae.en_US
dc.relation.ispartofScientific publications, vol.14, 2005-2007, no.1695en_US
dc.subjectcochlear implantsen_US
dc.titleAssessment of the protective effect of pneumococcal vaccination in preventing meningitis after cochlear implantationen_US
dc.typeJournal Articleen_US
melbourne.source.titleArchives of Otolaryngology - Head and Neck Surgeryen_US
melbourne.contributor.authorWei, Benjamin
melbourne.contributor.authorClark, Graeme
melbourne.contributor.authorO'Leary, Stephen
melbourne.contributor.authorShepherd, Robert
melbourne.contributor.authorRobins-Browne, Roy
melbourne.contributor.authorAZZOPARDI, KRISTY
melbourne.accessrightsThis item is currently not available from this repository

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