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    A Study of the Protective Function of Acute Morphine Administration on Subsequent Posttraumatic Stress Disorder

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    Author
    Bryant, RA; Creamer, M; O'Donnell, M; Silove, D; McFarlane, AC
    Date
    2009-03-01
    Source Title
    BIOLOGICAL PSYCHIATRY
    Publisher
    ELSEVIER SCIENCE INC
    University of Melbourne Author/s
    Creamer, Mark; O'Donnell, Meaghan
    Affiliation
    Psychiatry
    Metadata
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    Document Type
    Journal Article
    Citations
    Bryant, R. A., Creamer, M., O'Donnell, M., Silove, D. & McFarlane, A. C. (2009). A Study of the Protective Function of Acute Morphine Administration on Subsequent Posttraumatic Stress Disorder. BIOLOGICAL PSYCHIATRY, 65 (5), pp.438-440. https://doi.org/10.1016/j.biopsych.2008.10.032.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/27646
    DOI
    10.1016/j.biopsych.2008.10.032
    Description

    C1 - Journal Articles Refereed

    Abstract
    BACKGROUND: To index the extent to which acute administration of morphine is protective against development of posttraumatic stress disorder (PTSD). METHODS: Consecutive patients admitted to hospital after traumatic injury (n=155) were assessed for current psychiatric disorder, pain, and morphine dose in the initial week after injury and were reassessed for PTSD and other psychiatric disorders 3 months later (n=120). RESULTS: Seventeen patients (14%) met criteria for PTSD at 3 months. Patients who met criteria for PTSD received significantly less morphine than those who did not develop PTSD; there was no difference in morphine levels in those who did and did not develop major depressive episode or another anxiety disorder. Hierarchical regression analysis indicated that PTSD severity at 3 months was significantly predicted by acute pain, mild traumatic brain injury, and elevated morphine dose in the initial 48 hours after trauma, after controlling for injury severity, gender, age, and type of injury. CONCLUSIONS: Acute administration of morphine may limit fear conditioning in the aftermath of traumatic injury and may serve as a secondary prevention strategy to reduce PTSD development.
    Keywords
    Psychiatry (incl. Psychotherapy); Clinical Pharmacology and Therapeutics; Mental Health

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