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    Medial temporal lobe glutathione concentration in first episode psychosis: A H-1-MRS investigation

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    Author
    Wood, SJ; Berger, GE; Wellard, RM; Proffitt, T-M; McConchie, M; Berk, M; McGorry, PD; Pantelis, C
    Date
    2009-03-01
    Source Title
    NEUROBIOLOGY OF DISEASE
    Publisher
    ACADEMIC PRESS INC ELSEVIER SCIENCE
    University of Melbourne Author/s
    PROFFITT, TINA-MARIE; Berk, Michael; McGorry, Patrick; Pantelis, Christos; Wood, Stephen; Berger, Gregor; MCCONCHIE, MIRABEL
    Affiliation
    Psychiatry
    Metadata
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    Document Type
    Journal Article
    Citations
    Wood, S. J., Berger, G. E., Wellard, R. M., Proffitt, T. -M., McConchie, M., Berk, M., McGorry, P. D. & Pantelis, C. (2009). Medial temporal lobe glutathione concentration in first episode psychosis: A H-1-MRS investigation. NEUROBIOLOGY OF DISEASE, 33 (3), pp.354-357. https://doi.org/10.1016/j.nbd.2008.11.018.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/27660
    DOI
    10.1016/j.nbd.2008.11.018
    Description

    C1 - Journal Articles Refereed

    Abstract
    Glutathione (GSH) is implicated in the pathophysiology of schizophrenia. Previous brain spectroscopy studies, however, have been inconsistent, and there is little data available from first episode psychosis patients. This study compared brain GSH in a first episode cohort (n=30) to controls (n=18), using magnetic resonance spectroscopy (MRS), examining a temporal lobe voxel. Short-echo (TE 30 ms) acquisition proton MRS was performed on a 3T clinical magnetic resonance scanner. Comparison of the first-episode and control groups' GSH concentrations revealed a significant main effect of group (F(1,46)=4.7, p=0.035), but no main effect of hemisphere (F(1,46)=2.3, p=0.137) or group-by-side interactions (F(1,46)=0.4, p=0.513). Medial temporal lobe GSH concentrations in the first episode group were 22% higher than those in the control group. This study provides further evidence of significant perturbations in brain GSH in first episode psychosis, and supports a broader involvement of GSH in the pathophysiology of schizophrenia.
    Keywords
    Psychiatry (incl. Psychotherapy); Psychiatry ; Nervous System and Disorders; Nervous System and Disorders

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