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dc.contributor.authorWood, SJ
dc.contributor.authorBerger, GE
dc.contributor.authorWellard, RM
dc.contributor.authorProffitt, T-M
dc.contributor.authorMcConchie, M
dc.contributor.authorBerk, M
dc.contributor.authorMcGorry, PD
dc.contributor.authorPantelis, C
dc.date.available2014-05-21T20:39:17Z
dc.date.available2008-11-07
dc.date.available2008-11-07
dc.date.available2008-11-07
dc.date.available2008-11-07
dc.date.available2008-11-07
dc.date.available2008-11-07
dc.date.available2008-11-07
dc.date.available2008-11-07
dc.date.available2008-11-07
dc.date.issued2009-03-01
dc.identifierpii: S0969-9961(08)00276-3
dc.identifier.citationWood, S. J., Berger, G. E., Wellard, R. M., Proffitt, T. -M., McConchie, M., Berk, M., McGorry, P. D. & Pantelis, C. (2009). Medial temporal lobe glutathione concentration in first episode psychosis: A H-1-MRS investigation. NEUROBIOLOGY OF DISEASE, 33 (3), pp.354-357. https://doi.org/10.1016/j.nbd.2008.11.018.
dc.identifier.issn0969-9961
dc.identifier.urihttp://hdl.handle.net/11343/27660
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractGlutathione (GSH) is implicated in the pathophysiology of schizophrenia. Previous brain spectroscopy studies, however, have been inconsistent, and there is little data available from first episode psychosis patients. This study compared brain GSH in a first episode cohort (n=30) to controls (n=18), using magnetic resonance spectroscopy (MRS), examining a temporal lobe voxel. Short-echo (TE 30 ms) acquisition proton MRS was performed on a 3T clinical magnetic resonance scanner. Comparison of the first-episode and control groups' GSH concentrations revealed a significant main effect of group (F(1,46)=4.7, p=0.035), but no main effect of hemisphere (F(1,46)=2.3, p=0.137) or group-by-side interactions (F(1,46)=0.4, p=0.513). Medial temporal lobe GSH concentrations in the first episode group were 22% higher than those in the control group. This study provides further evidence of significant perturbations in brain GSH in first episode psychosis, and supports a broader involvement of GSH in the pathophysiology of schizophrenia.
dc.languageEnglish
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.subjectPsychiatry (incl. Psychotherapy); Psychiatry ; Nervous System and Disorders; Nervous System and Disorders
dc.titleMedial temporal lobe glutathione concentration in first episode psychosis: A H-1-MRS investigation
dc.typeJournal Article
dc.identifier.doi10.1016/j.nbd.2008.11.018
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentPsychiatry
melbourne.source.titleNEUROBIOLOGY OF DISEASE
melbourne.source.volume33
melbourne.source.issue3
melbourne.source.pages354-357
dc.research.codefor110319
dc.research.coderfcd321021
dc.research.codeseo1998730104
dc.research.codeseo2008920111
melbourne.publicationid119535
melbourne.elementsid308381
melbourne.contributor.authorPROFFITT, TINA-MARIE
melbourne.contributor.authorBerk, Michael
melbourne.contributor.authorMcGorry, Patrick
melbourne.contributor.authorPantelis, Christos
melbourne.contributor.authorWood, Stephen
melbourne.contributor.authorBerger, Gregor
melbourne.contributor.authorMCCONCHIE, MIRABEL
dc.identifier.eissn1095-953X
pubs.acceptance.date2008-11-07
melbourne.accessrightsThis item is currently not available from this repository


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