Long-Term Follow-Up of Schistosomiasis Serology Post-Treatment in Australian Travelers and Immigrants
AuthorYong, MK; Beckett, CL; Leder, K; Biggs, BA; Torresi, J; O'Brien, DP
Source TitleJOURNAL OF TRAVEL MEDICINE
PublisherWILEY-BLACKWELL PUBLISHING, INC
AffiliationMedicine - Royal Melbourne Hospital
Document TypeJournal Article
CitationsYong, M. K., Beckett, C. L., Leder, K., Biggs, B. A., Torresi, J. & O'Brien, D. P. (2010). Long-Term Follow-Up of Schistosomiasis Serology Post-Treatment in Australian Travelers and Immigrants. JOURNAL OF TRAVEL MEDICINE, 17 (2), pp.89-93. https://doi.org/10.1111/j.1708-8305.2009.00379.x.
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C1 - Journal Articles Refereed
BACKGROUND: We undertook an observational follow-up study of schistosomiasis serology in both travelers and immigrants in a nonendemic country to determine the natural history of schistosomiasis antibody titer post-adequate treatment in those who have not been reexposed. METHODS: Longitudinal study of all adult travelers and immigrants presenting to the Royal Melbourne Hospital, Australia with positive schistosomiasis serology (titer >1: 64) between July 1995 and December 2005. All patients were treated with praziquantel and followed up clinically and serologically for a period up to 30 months. RESULTS: A total of 58 patients were included in the study including 26 travelers and 32 immigrants. Antibody titers often increased in the first 6 to 12 months post-treatment, especially in immigrants. After 30 months of post-treatment, 68% of travelers and 35% of immigrants (p < 0.01) achieved a fourfold antibody decline. CONCLUSIONS: Schistosomiasis antibody titers varied after adequate treatment. Therefore an increase in titer in the first 6 to 12 months or a failure to reduce after 3 years should not automatically justify re-treatment.
KeywordsInfectious Diseases; Infectious Diseases
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