Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder diagnosed by difficulties in social communication, repetitive behaviour and/or restricted interests. A high proportion of ASD patients also experience ...

Spasticity is a common manifestation of a neurological condition such as stroke and contributes to long-term disability. Spasticity is disordered sensorimotor control that results from damage to upper motor neurons and ...

The glycoprotein reelin is integral for brain development and maintaining synaptic plasticity, and its expression is reduced in schizophrenia brains. Whether stress, a risk factor for schizophrenia, is mediated by altered ...

Parkinson`s disease (PD) and Ischemic stroke are common disorders in our aging population. Although a large body of basic research highlights the potential of cell replacement therapy (CRT) as a novel therapeutic approach, ...

Human communication frequently takes place in noisy environments. In these environments, successful understanding of speech is dependent on an individual’s ability to extract and use spatial cues for separating speech from ...

Due to significant midbrain dopamine (DA) cell loss in Parkinson’s disease (PD), it is generally believed the most effective and long-term treatment for PD motor symptoms will be midbrain DA cell replacement therapy, either ...

Knee osteoarthritis (OA) is a major cause of disability and it is a growing problem due to the aging population and rising obesity rates. Better understanding of the disease process is required to inform the most efficient ...

Oligodendrocyte differentiation and the myelination of axons are crucial aspects of vertebrate central nervous system development and function. The processes of oligodendrocyte differentiation and the expression of these ...

Renal fibrosis (scarring) is a hallmark of chronic kidney disease and is characterized by an excessive accumulation of extracellular matrix (ECM) proteins, primarily collagen. Driven by the continuous exposure to pathological ...

Sepsis is a leading cause of hospital morbidity and mortality causing organ failure with the kidney being commonly affected. Unfortunately, the pathophysiology of septic acute kidney injury (AKI) is poorly understood. Renal ...