Centre for Neuroscience - Theses
Now showing items 1-10 of 35
Tau and beta-amyloid deposition, structural integrity, and cognitive function following traumatic brain injury in Australian war veterans
Background: Traumatic brain injury (TBI), has been diagnosed in over 355,000 US military service personnel since 2000. Epidemiological research indicates that veterans with TBI are two-to-four times more likely to develop ...
Investigating cortical oscillations, coherence and seizure susceptibility in a mouse model of autism
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder diagnosed by difficulties in social communication, repetitive behaviour and/or restricted interests. A high proportion of ASD patients also experience ...
Rehabilitation management of post-stroke spasticity
Spasticity is a common manifestation of a neurological condition such as stroke and contributes to long-term disability. Spasticity is disordered sensorimotor control that results from damage to upper motor neurons and ...
The role of steroid hormones in schizophrenia: unravelling the mechanism of 17-beta estradiol and raloxifene on cognitive function
The glycoprotein reelin is integral for brain development and maintaining synaptic plasticity, and its expression is reduced in schizophrenia brains. Whether stress, a risk factor for schizophrenia, is mediated by altered ...
Cell based restoration of motor function in rodent models of Parkinson's disease and stroke
Parkinson`s disease (PD) and Ischemic stroke are common disorders in our aging population. Although a large body of basic research highlights the potential of cell replacement therapy (CRT) as a novel therapeutic approach, ...
Investigating the effect of spatial separation on the detection of sounds in competition, by examining electrophysiological responses from the brainstem and auditory cortex
Human communication frequently takes place in noisy environments. In these environments, successful understanding of speech is dependent on an individual’s ability to extract and use spatial cues for separating speech from ...
An anatomical and single-cell gene expression characterisation of putative neurogenesis from nestin-expressing cells in the adult mouse midbrain
Due to significant midbrain dopamine (DA) cell loss in Parkinson’s disease (PD), it is generally believed the most effective and long-term treatment for PD motor symptoms will be midbrain DA cell replacement therapy, either ...
Sensorimotor changes in knee osteoarthritis: from muscle spindle function to brain organisation and activity
Knee osteoarthritis (OA) is a major cause of disability and it is a growing problem due to the aging population and rising obesity rates. Better understanding of the disease process is required to inform the most efficient ...
Transcriptional control of myelin maintenance in the adult CNS
Oligodendrocyte differentiation and the myelination of axons are crucial aspects of vertebrate central nervous system development and function. The processes of oligodendrocyte differentiation and the expression of these ...
Molecular mechanisms of relaxin in renal fibrosis
Renal fibrosis (scarring) is a hallmark of chronic kidney disease and is characterized by an excessive accumulation of extracellular matrix (ECM) proteins, primarily collagen. Driven by the continuous exposure to pathological ...