Investigation of reproductive toxicity of piperaquine in mice
AuthorBatty, KT; Moore, BR; Stirling, V; Ilett, KF; Page-Sharp, M; Shilkin, KB; Mueller, I; Rogerson, SJ; Karunajeewa, HA; Davis, TME
Source TitleREPRODUCTIVE TOXICOLOGY
PublisherPERGAMON-ELSEVIER SCIENCE LTD
AffiliationMedicine - Royal Melbourne Hospital
Document TypeJournal Article
CitationsBatty, K. T., Moore, B. R., Stirling, V., Ilett, K. F., Page-Sharp, M., Shilkin, K. B., Mueller, I., Rogerson, S. J., Karunajeewa, H. A. & Davis, T. M. E. (2010). Investigation of reproductive toxicity of piperaquine in mice. REPRODUCTIVE TOXICOLOGY, 29 (2), pp.206-213. https://doi.org/10.1016/j.reprotox.2009.10.013.
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C1 - Journal Articles Refereed
Reproductive toxicity data for the antimalarial drug piperaquine (PQ) were obtained in pregnant mice (F(0)) and their offspring (F(1) and F(2)). PQ phosphate (0-300 mg/kg/day) was given to pregnant Swiss mice from gestational days 14-18. Two F(1) pups from each litter (one male and one female) proceeded to maturity and were mated within dose groups. Biochemical and haematological indices were determined, and liver and kidney histopathology was assessed in F(1) and F(2) mice at 4 weeks. There were no significant dose-related adverse effects, but leucocytes were mildly elevated (F(1) and F(2) mice) and serum albumin was reduced (F(1) only) in the 300 mg/kg/day group. Low plasma PQ concentrations were detected in F(1) mice at 4 and 8 weeks. Although we found no significant PQ toxicity, clinical data are lacking and monitoring of women and their infants for biochemical and haematological adverse effects is recommended when PQ is used in pregnancy.
KeywordsMedical Parasitology; Infectious Diseases; Reproductive System and Disorders
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