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dc.contributor.authorBatty, KT
dc.contributor.authorMoore, BR
dc.contributor.authorStirling, V
dc.contributor.authorIlett, KF
dc.contributor.authorPage-Sharp, M
dc.contributor.authorShilkin, KB
dc.contributor.authorMueller, I
dc.contributor.authorRogerson, SJ
dc.contributor.authorKarunajeewa, HA
dc.contributor.authorDavis, TME
dc.date.available2014-05-21T20:48:42Z
dc.date.available2009-10-28
dc.date.available2009-10-28
dc.date.available2009-10-28
dc.date.available2009-10-28
dc.date.available2009-10-28
dc.date.available2009-10-28
dc.date.available2009-10-28
dc.date.available2009-10-28
dc.date.issued2010-04-01
dc.identifierpii: S0890-6238(09)00315-3
dc.identifier.citationBatty, K. T., Moore, B. R., Stirling, V., Ilett, K. F., Page-Sharp, M., Shilkin, K. B., Mueller, I., Rogerson, S. J., Karunajeewa, H. A. & Davis, T. M. E. (2010). Investigation of reproductive toxicity of piperaquine in mice. REPRODUCTIVE TOXICOLOGY, 29 (2), pp.206-213. https://doi.org/10.1016/j.reprotox.2009.10.013.
dc.identifier.issn0890-6238
dc.identifier.urihttp://hdl.handle.net/11343/27805
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractReproductive toxicity data for the antimalarial drug piperaquine (PQ) were obtained in pregnant mice (F(0)) and their offspring (F(1) and F(2)). PQ phosphate (0-300 mg/kg/day) was given to pregnant Swiss mice from gestational days 14-18. Two F(1) pups from each litter (one male and one female) proceeded to maturity and were mated within dose groups. Biochemical and haematological indices were determined, and liver and kidney histopathology was assessed in F(1) and F(2) mice at 4 weeks. There were no significant dose-related adverse effects, but leucocytes were mildly elevated (F(1) and F(2) mice) and serum albumin was reduced (F(1) only) in the 300 mg/kg/day group. Low plasma PQ concentrations were detected in F(1) mice at 4 and 8 weeks. Although we found no significant PQ toxicity, clinical data are lacking and monitoring of women and their infants for biochemical and haematological adverse effects is recommended when PQ is used in pregnancy.
dc.languageEnglish
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.subjectMedical Parasitology; Infectious Diseases; Reproductive System and Disorders
dc.titleInvestigation of reproductive toxicity of piperaquine in mice
dc.typeJournal Article
dc.identifier.doi10.1016/j.reprotox.2009.10.013
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMedicine - Royal Melbourne Hospital
melbourne.source.titleREPRODUCTIVE TOXICOLOGY
melbourne.source.volume29
melbourne.source.issue2
melbourne.source.pages206-213
dc.research.codefor110803
dc.research.codeseo2008920109
dc.research.codeseo2008920114
melbourne.publicationid139634
melbourne.elementsid319497
melbourne.contributor.authorRogerson, Stephen
melbourne.contributor.authorKarunajeewa, Harin
dc.identifier.eissn1873-1708
pubs.acceptance.date2009-10-28
melbourne.accessrightsThis item is currently not available from this repository


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