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dc.contributor.authorHommel, M
dc.contributor.authorElliott, SR
dc.contributor.authorSoma, V
dc.contributor.authorKelly, G
dc.contributor.authorFowkes, FJI
dc.contributor.authorChesson, JM
dc.contributor.authorDuffy, MF
dc.contributor.authorBockhorst, J
dc.contributor.authorAvril, M
dc.contributor.authorMueller, I
dc.contributor.authorRaiko, A
dc.contributor.authorStanisic, DI
dc.contributor.authorRogerson, SJ
dc.contributor.authorSmith, JD
dc.contributor.authorBeeson, JG
dc.date.available2014-05-21T20:48:47Z
dc.date.issued2010-05-01
dc.identifierpii: IAI.01365-09
dc.identifier.citationHommel, M., Elliott, S. R., Soma, V., Kelly, G., Fowkes, F. J. I., Chesson, J. M., Duffy, M. F., Bockhorst, J., Avril, M., Mueller, I., Raiko, A., Stanisic, D. I., Rogerson, S. J., Smith, J. D. & Beeson, J. G. (2010). Evaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant Women. INFECTION AND IMMUNITY, 78 (5), pp.1963-1978. https://doi.org/10.1128/IAI.01365-09.
dc.identifier.issn0019-9567
dc.identifier.urihttp://hdl.handle.net/11343/27806
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractPregnant women are infected by specific variants of Plasmodium falciparum that adhere and accumulate in the placenta. Using serological and molecular approaches, we assessed the global antigenic diversity of surface antigens expressed by placenta-binding isolates to better understand immunity to malaria in pregnancy and evolution of polymorphisms and to inform vaccine development. We found that placenta-binding isolates originating from all major regions where malaria occurs were commonly recognized by antibodies in different populations of pregnant women. There was substantial antigenic overlap and sharing of epitopes between isolates, including isolates from distant geographic locations, suggesting that there are limitations to antigenic diversity; however, differences between populations and isolates were also seen. Many women had cross-reactive antibodies and/or a broad repertoire of antibodies to different isolates. Studying VAR2CSA as the major antigen expressed by placenta-binding isolates, we identified antibody epitopes encoded by variable sequence blocks in the DBL3 domain. Analysis of global var2csa DBL3 sequences demonstrated that there was extensive sharing of variable blocks between Africa, Asia, Papua New Guinea, and Latin America, which likely contributes to the high level of antigenic overlap between different isolates. However, there was also evidence of geographic clustering of sequences and differences in VAR2CSA sequences between populations. The results indicate that there is limited antigenic diversity in placenta-binding isolates and may explain why immunity to malaria in pregnancy can be achieved after exposure during one pregnancy. Inclusion of a limited number of variants in a candidate vaccine may be sufficient for broad population coverage, but geographic considerations may also have to be included in vaccine design.
dc.languageEnglish
dc.publisherAMER SOC MICROBIOLOGY
dc.subjectInfectious Diseases; Infectious Diseases
dc.titleEvaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant Women
dc.typeJournal Article
dc.identifier.doi10.1128/IAI.01365-09
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMedicine - Royal Melbourne Hospital
melbourne.source.titleINFECTION AND IMMUNITY
melbourne.source.volume78
melbourne.source.issue5
melbourne.source.pages1963-1978
dc.research.codefor110309
dc.research.codeseo2008920109
melbourne.publicationid143256
melbourne.elementsid321850
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863515
melbourne.contributor.authorDuffy, Michael
melbourne.contributor.authorRogerson, Stephen
melbourne.contributor.authorFowkes, Freya
melbourne.contributor.authorKELLY, GREGORY LEO
melbourne.contributor.authorBeeson, James
dc.identifier.eissn1098-5522
melbourne.accessrightsAccess this item via the Open Access location


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