Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria
AuthorVijay, R; Guthmiller, JJ; Sturtz, AJ; Surette, FA; Rogers, KJ; Sompallae, RR; Li, F; Pope, RL; Chan, J-A; Rivera, FDL; ...
Source TitleNature Immunology
University of Melbourne Author/sMcCarthy, James
AffiliationMelbourne Medical School
Document TypeJournal Article
CitationsVijay, R., Guthmiller, J. J., Sturtz, A. J., Surette, F. A., Rogers, K. J., Sompallae, R. R., Li, F., Pope, R. L., Chan, J. -A., Rivera, F. D. L., Andrew, D., Webb, L., Maury, W. J., Xue, H. -H., Engwerda, C. R., McCarthy, J. S., Boyle, M. J. & Butler, N. S. (2020). Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria. Nature Immunology, 21 (7), pp.790-+. https://doi.org/10.1038/s41590-020-0678-5.
Access StatusAccess this item via the Open Access location
Open Access URLPublished version
Plasmodium parasite–specific antibodies are critical for protection against malaria, yet the development of long-lived and effective humoral immunity against Plasmodium takes many years and multiple rounds of infection and cure. Here, we report that the rapid development of short-lived plasmablasts during experimental malaria unexpectedly hindered parasite control by impeding germinal center responses. Metabolic hyperactivity of plasmablasts resulted in nutrient deprivation of the germinal center reaction, limiting the generation of memory B cell and long-lived plasma cell responses. Therapeutic administration of a single amino acid to experimentally infected mice was sufficient to overcome the metabolic constraints imposed by plasmablasts and enhanced parasite clearance and the formation of protective humoral immune memory responses. Thus, our studies not only challenge the current model describing the role and function of blood-stage Plasmodium-induced plasmablasts but they also reveal new targets and strategies to improve anti-Plasmodium humoral immunity.
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References