Show simple item record

dc.contributor.authorHurley, JC
dc.date.accessioned2021-08-18T23:28:12Z
dc.date.available2021-08-18T23:28:12Z
dc.date.issued2021-06-01
dc.identifier.citationHurley, J. C. (2021). Asymmetric Effects of Decontamination Using Topical Antibiotics for the ICU Patient. SYMMETRY-BASEL, 13 (6), https://doi.org/10.3390/sym13061027.
dc.identifier.issn2073-8994
dc.identifier.urihttp://hdl.handle.net/11343/280996
dc.description.abstractThere are several antiseptic, antibiotic and non-decontamination-based interventions for preventing intensive care unit (ICU) acquired infection. These have been evaluated in >200 studies. Infection prevention using topical antibiotic prophylaxis (TAP) appears to be the most effective. Whether antibiotic use in the ICU may influence the risk of infection among concurrent control patients within the same ICU and result in asymmetrical herd effects cannot be resolved with individual studies examined in isolation. The collective observations within control and intervention groups from numerous ICU infection prevention studies simulates a multi-center natural experiment enabling the herd effects of antibiotics to be evaluated. Among the TAP control groups, the incidences for both ventilator associated pneumonia (VAP) and mortality are unusually high in comparison to literature-derived benchmarks. Paradoxically, amongst the TAP intervention groups, the incidences of mortality are also unusually high and the VAP incidences are similar (i.e., not lower) compared to the incidences among studies of other interventions. By contrast, the mortality incidences among the intervention groups of other studies are similar to those among the intervention groups of TAP studies. Using topical antibiotics to prevent infections acquired within the ICU environment may result in profoundly asymmetrical effects.
dc.languageEnglish
dc.publisherMDPI
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleAsymmetric Effects of Decontamination Using Topical Antibiotics for the ICU Patient
dc.typeJournal Article
dc.identifier.doi10.3390/sym13061027
melbourne.affiliation.departmentRural Clinical School
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleSymmetry
melbourne.source.volume13
melbourne.source.issue6
dc.rights.licenseCC BY
melbourne.elementsid1543927
melbourne.contributor.authorHurley, James
dc.identifier.eissn2073-8994
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record