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dc.contributor.authorTsoi, Edward Hao Jun
dc.date.accessioned2021-09-15T00:15:14Z
dc.date.available2021-09-15T00:15:14Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/11343/283390
dc.description© 2021 Edward Hao Jun Tsoi
dc.description.abstractEndoscopic mucosal resection (EMR) and radiofrequency ablation (RFA) are safe and effective for management of Barrett’s oesophagus with dysplasia; however, some patients have a poor response to RFA, and recurrence of dysplasia can occur. There are controversies surrounding the management of Barrett’s oesophagus with low grade dysplasia (LGD) due to the conflicting data in the literature on diagnosis and progression rate. This thesis describes the long-term outcomes of endoscopic eradication therapy in management of dysplastic Barrett’s oesophagus and factors associated with poor response to RFA. In addition, this thesis also addresses the wide range of progression rate of LGD in the literature, investigates the use of specific histologic criteria to predict progression from LGD and describes a different phenotype of LGD in Barrett’s oesophagus.
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dc.subjectBarrett’s oesophagus
dc.subjectLow grade dysplasia
dc.subjectEndoscopic mucosa resection
dc.subjectRadiofrequency ablation
dc.subjectEndoscopic eradication therapy
dc.subjectResponse
dc.subjectProgression
dc.subjectHistologic criteria
dc.subjectDEVLB
dc.titleAddressing Controversies in the Management of Barrett’s Oesophagus Related Dysplasia
dc.typePhD thesis
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.affiliation.facultyMelbourne Medical School
melbourne.thesis.supervisornameAndrew Taylor
melbourne.contributor.authorTsoi, Edward Hao Jun
melbourne.thesis.supervisorothernamePaul Desmond
melbourne.tes.fieldofresearch1320209 Gastroenterology and hepatology
melbourne.accessrightsOpen Access


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