Show simple item record

dc.contributor.authorHo, CYD
dc.contributor.authorLek, JJ
dc.contributor.authorAung, KZ
dc.contributor.authorMcGuinness, MB
dc.contributor.authorLuu, CD
dc.contributor.authorGuymer, RH
dc.date.accessioned2021-09-17T00:39:08Z
dc.date.available2021-09-17T00:39:08Z
dc.date.issued2018-07-01
dc.identifier.citationHo, C. Y. D., Lek, J. J., Aung, K. Z., McGuinness, M. B., Luu, C. D. & Guymer, R. H. (2018). Relationship between reticular pseudodrusen and choroidal thickness in intermediate age-related macular degeneration. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 46 (5), pp.485-494. https://doi.org/10.1111/ceo.13131.
dc.identifier.issn1442-6404
dc.identifier.urihttp://hdl.handle.net/11343/283445
dc.description.abstractIMPORTANCE: Reticular pseudodrusen (RPD) is strongly associated with late age-related macular degeneration (AMD) but their aetiology remains unknown. RPD have been associated with reduced choroidal thickness (ChT) but most studies are limited by small sample size and varying severity of AMD. BACKGROUND: To investigate the relationship between choroidal thickness and RPD in eyes with intermediate AMD (iAMD), controlling for variables known to influence ChT. DESIGN: Retrospective cohort study. PARTICIPANTS: Participants were recruited from Centre for Eye Research Australia. METHODS: Colour fundus photographs, fundus auto fluorescence, near-infrared and spectral-domain ocular coherence tomography (OCT) were graded for RPD. ChT was measured from enhanced-depth imaging OCT scans at the centre of fovea, 1500 and 3000 μm nasal, temporal, superior and inferior from centre of fovea. MAIN OUTCOME MEASURES: ChT between RPD and non-RPD group. RESULTS: A total of 297 eyes from 152 subjects were included. A total of 84 (28%) had RPD and were older than non-RPD group (75.1 ± 5.4 years and 68.7 ± 6.9 years, respectively; P < 0.001). In unadjusted analysis, the RPD group was significantly associated with thinner choroids across all measured locations (P ≤ 0.022). After adjustment for variables, the presence of RPD was no longer associated with ChT (P ≥ 0.132 for all locations) but age (P < 0.001) and refractive error (P = 0.002) remained significantly associated with ChT. CONCLUSIONS AND RELEVANCE: Age and refractive error, rather than RPD, was significantly associated with reduced ChT in eyes with iAMD. Choroidal insufficiency may be a less important variable in RPD aetiology than previously considered.
dc.languageEnglish
dc.publisherWILEY
dc.titleRelationship between reticular pseudodrusen and choroidal thickness in intermediate age-related macular degeneration
dc.typeJournal Article
dc.identifier.doi10.1111/ceo.13131
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentCentre for Eye Research Australia (CERA)
melbourne.affiliation.departmentOptometry and Vision Sciences
melbourne.affiliation.departmentOphthalmology (Eye & Ear Hospital)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.affiliation.facultyAffiliate
melbourne.affiliation.facultyScience
melbourne.source.titleClinical and Experimental Ophthalmology
melbourne.source.volume46
melbourne.source.issue5
melbourne.source.pages485-494
melbourne.elementsid1285212
melbourne.contributor.authorLuu, Chi
melbourne.contributor.authorGuymer, Robyn
melbourne.contributor.authorLek, Jia Jia
melbourne.contributor.authorLuu, Chi
melbourne.contributor.authorMcGuinness, Myra
dc.identifier.eissn1442-9071
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record