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dc.contributor.authorMcLure, CA
dc.contributor.authorDawkins, RL
dc.contributor.authorWilliamson, JF
dc.contributor.authorDavies, RA
dc.contributor.authorBerry, J
dc.contributor.authorNatalie, L-J
dc.contributor.authorLaird, R
dc.contributor.authorGaudieri, S
dc.identifier.citationMcLure, C. A., Dawkins, R. L., Williamson, J. F., Davies, R. A., Berry, J., Natalie, L. -J., Laird, R. & Gaudieri, S. (2004). Amino acid patterns within short consensus repeats define conserved duplicons shared by genes of the RCA complex.. J Mol Evol, 59 (2), pp.143-157.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractComplement control proteins (CCPs) contain repeated protein domains, short consensus repeats (SCRs), which must be relevant to diverse functions such as complement activation, coagulation, viral binding, fetal implantation, and self-nonself recognition. Although SCRs share some discontinuous and imperfect motifs, there are many variable positions and indels making classification in subfamilies extremely difficult. Using domain-by-domain phylogenetic analysis, we have found that most domains can be classified into only 11 subfamilies, designated a, b, c, d, e, f, g, h, i, j, or k and identified by critical residues. Each particular CCP is characterized by the order of representatives of the subfamilies. Human complement receptor 1 (CR1) has ajefbkd repeated four times and followed by ch. The classification crosses CCPs and indicates that a particular CCP is a function of the mix of SCRs. The aje set is a feature of several CCPs including human CR1 and DAF and murine Crry and appears to be associated with the success or failure of implantation inter alia. This approach facilitates genomic analysis of available sequences and suggests a framework for the evolution of CCPs. Units of duplication range from single SCRs, to septamers such as efbkdaj, to extensive segments such as MCP-CR1L. Imperfections of duplication with subsequent deletion have contributed to diversification.
dc.publisherSpringer Science and Business Media LLC
dc.subjectPhylogeny and Comparative Analysis; Genetic Immunology; Genomics; Molecular Evolution; Innate Immunity; Expanding Knowledge in the Biological Sciences; Expanding Knowledge in the Medical and Health Sciences
dc.titleAmino acid patterns within short consensus repeats define conserved duplicons shared by genes of the RCA complex.
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentVeterinary Science
melbourne.source.titleJournal of Molecular Evolution
melbourne.contributor.authorMCLURE, CRAIG
melbourne.fieldofresearch320407 Innate immunity
melbourne.seocode280102 Expanding knowledge in the biological sciences
melbourne.accessrightsThis item is currently not available from this repository

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