APASL clinical practice guideline on hepatitis B reactivation related to the use of immunosuppressive therapy.
AuthorLau, G; Yu, M-L; Wong, G; Thompson, A; Ghazinian, H; Hou, J-L; Piratvisuth, T; Jia, J-D; Mizokami, M; Cheng, G; ...
Source TitleHepatology International
PublisherSpringer Science and Business Media LLC
University of Melbourne Author/sThompson, Alexander
AffiliationMedicine (St Vincent's)
Document TypeJournal Article
CitationsLau, G., Yu, M. -L., Wong, G., Thompson, A., Ghazinian, H., Hou, J. -L., Piratvisuth, T., Jia, J. -D., Mizokami, M., Cheng, G., Chen, G. -F., Liu, Z. -W., Baatarkhuu, O., Cheng, A. L., Ng, W. L., Lau, P., Mok, T., Chang, J. -M., Hamid, S. ,... Omata, M. (2021). APASL clinical practice guideline on hepatitis B reactivation related to the use of immunosuppressive therapy.. Hepatol Int, 15 (5), pp.1031-1048. https://doi.org/10.1007/s12072-021-10239-x.
Access StatusAccess this item via the Open Access location
Open Access URLPublished version
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC8382940
BACKGROUND & AIM: Hepatitis B reactivation related to the use of immunosuppressive therapy remains a major cause of liver-related morbidity and mortality in hepatitis B endemic Asia-Pacific region. This clinical practice guidelines aim to assist clinicians in all disciplines involved in the use of immunosuppressive therapy to effectively prevent and manage hepatitis B reactivation. METHODS: All publications related to hepatitis B reactivation with the use of immunosuppressive therapy since 1975 were reviewed. Advice from key opinion leaders in member countries/administrative regions of Asian-Pacific Association for the study of the liver was collected and synchronized. Immunosuppressive therapy was risk-stratified according to its reported rate of hepatitis B reactivation. RECOMMENDATIONS: We recommend the necessity to screen all patients for hepatitis B prior to the initiation of immunosuppressive therapy and to administer pre-emptive nucleos(t)ide analogues to those patients with a substantial risk of hepatitis and acute-on-chronic liver failure due to hepatitis B reactivation.
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