Security-oriented data grids for microarray expression profiles
AuthorSINNOTT, RICHARD; BAYLISS, CHRISTOPHER; Jiang, Jipu
Source TitleStudies in Health Technology and Informatics
Document TypeJournal Article
CitationsSinnott, R., Bayliss, C., & Jiang, J. (2007). Security-oriented data grids for microarray expression profiles. Studies in Health Technology and Informatics, 126, 67-76.
Access StatusOpen Access
This is a post-print of an article published in Studies in Health Technology and Informatics 2007 published by IOS Press. http://booksonline.iospress.nl/Content/View.aspx?piid=5551
Microarray experiments are one of the key ways in which gene activity can be identified and measured thereby shedding light and understanding for example on biological processes. The BBSRC funded Grid enabled Microarray Expression Profile Search (GEMEPS) project has developed an infrastructure which allows post-genomic life science researchers to ask and answer the following questions: who has undertaken microarray experiments that are in some way similar or relevant to mine; and how similar were these relevant experiments? Given that microarray experiments are expensive to undertake and may possess crucial information for future exploitation (both academically and commercially), scientists are wary of allowing unrestricted access to their data by the wider community until fully exploited locally. A key requirement is thus to have fine grained security that is easy to establish and simple (or ideally transparent) to use across inter-institutional virtual organisations. In this paper we present an enhanced security-oriented data Grid infrastructure that supports the definition of these kinds of queries and the analysis and comparison of microarray experiment results.
Keywordsmicroarray expression profiles; grid security; shibboleth
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