Show simple item record

dc.contributor.authorEvin, G
dc.contributor.authorKenche, VB
dc.identifier.citationEvin, G. & Kenche, V. B. (2007). BACE inhibitors as potential therapeutics for Alzheimer's disease.. Recent Pat CNS Drug Discov, 2 (3), pp.188-199.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractAccumulation of Abeta peptide in the brain results in the formation of amyloid plaques characteristic of Alzheimer's disease (AD) pathology. Abeta soluble oligomers and protofibrils are neurotoxic and these are believed to be a major cause of neurodegeneration in AD. Abeta is derived from a precursor protein by two sequential cleavage steps involving beta- and gamma-secretases, two proteolytic enzymes that represent rational drug targets. beta-secretase was identified as the membrane-anchored aspartyl protease BACE (or BACE1) and found to be elevated in brain cortex of patients with sporadic Alzheimer's disease. In this review, we summarize current approaches towards the development of BACE inhibitors with focus on bioactive compounds and related patents. Recent reports have described drugs that are effective at inhibiting Abeta production in the brain of transgenic mouse models. The beginning of Phase I clinical trials has been approved for one of them and we can expect that in the near future BACE inhibitors will provide novel effective therapeutics to treat AD.
dc.publisherBentham Science Publishers Ltd.
dc.subjectNeurology and Neuromuscular Diseases; Neurodegenerative Disorders Related to Ageing
dc.titleBACE inhibitors as potential therapeutics for Alzheimer's disease.
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.source.titleRecent Pat CNS Drug Discov
melbourne.contributor.authorEvin, Genevieve
melbourne.contributor.authorKenche, Vijaya
melbourne.fieldofresearch320905 Neurology and neuromuscular diseases
melbourne.seocode200199 Clinical health not elsewhere classified
melbourne.accessrightsThis item is currently not available from this repository

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record