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dc.contributor.authorMellor, K
dc.contributor.authorRitchie, RH
dc.contributor.authorMeredith, G
dc.contributor.authorWoodman, OL
dc.contributor.authorMorris, MJ
dc.contributor.authorDelbridge, LMD
dc.date.available2014-05-21T22:13:45Z
dc.date.available2009-08-10
dc.date.available2009-08-10
dc.date.available2009-08-10
dc.date.available2009-08-10
dc.date.available2009-08-10
dc.date.available2009-08-10
dc.date.available2009-08-10
dc.date.available2009-08-10
dc.date.available2009-08-10
dc.date.issued2010-07-01
dc.identifierpii: S0899-9007(09)00342-6
dc.identifier.citationMellor, K., Ritchie, R. H., Meredith, G., Woodman, O. L., Morris, M. J. & Delbridge, L. M. D. (2010). High-fructose diet elevates myocardial superoxide generation in mice in the absence of cardiac hypertrophy. NUTRITION, 26 (7-8), pp.842-848. https://doi.org/10.1016/j.nut.2009.08.017.
dc.identifier.issn0899-9007
dc.identifier.urihttp://hdl.handle.net/11343/28901
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractOBJECTIVE: Dietary fructose intake has increased considerably in recent decades and this has been paralleled by an increase in the incidence of insulin resistance, especially in children and adolescents. The impact of a high-fructose diet on the myocardium is not fully understood. The aims of this study were to characterize the murine metabolic and cardiac phenotypes associated with a high-fructose diet and to determine whether this diet imparts differential effects with age. METHODS: Juvenile (4 wk) and adult (14 wk) C57Bl/6 mice were fed a 60% fructose diet or isoenergetic control (starch) diet for 6 wk. RESULTS: At completion of the dietary intervention (at ages 10 and 20 wk), fructose-fed mice were normotensive; hyperinsulinemia and cardiac hypertrophy were not evident. Interestingly, fructose-fed mice exhibited lower blood glucose levels (10 wk: 4.81+/-0.28 versus 5.42+/-0.31 mmol/L; 20 wk: 4.88+/-0.30 versus 5.96+/-0.42 mmol/L, P<0.05) compared with controls. Nicotinamide adenosine dinucleotide phosphate-driven myocardial superoxide production was significantly increased in fructose-fed mice at both ages (by approximately 29% of control at 10 wk of age and 16% at 20 wk, P<0.01). No increase in aortic superoxide production was observed. Fructose feeding did not alter gene expression of the antioxidant thioredoxin-2, suggesting an imbalance between myocardial reactive oxygen species generation and antioxidant induction. CONCLUSION: These findings indicate that increased myocardial superoxide production may represent an early and primary cardiac pathologic response to the metabolic challenge of excess dietary fructose in juveniles and adults that can be detected in the absence of cardiac hypertrophy and hypertension.
dc.languageEnglish
dc.publisherELSEVIER SCIENCE INC
dc.subjectSystems Physiology; Cardiovascular System and Diseases
dc.titleHigh-fructose diet elevates myocardial superoxide generation in mice in the absence of cardiac hypertrophy
dc.typeJournal Article
dc.identifier.doi10.1016/j.nut.2009.08.017
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentPhysiology
melbourne.source.titleNutrition
melbourne.source.volume26
melbourne.source.issue7-8
melbourne.source.pages842-848
melbourne.publicationid141880
melbourne.elementsid320948
melbourne.contributor.authorMELLOR, KIMBERLEY
melbourne.contributor.authorDelbridge, Leanne
melbourne.contributor.authorMEREDITH, GRETA
dc.identifier.eissn1873-1244
melbourne.fieldofresearch320803 Systems physiology
melbourne.seocode200199 Clinical health not elsewhere classified
melbourne.accessrightsThis item is currently not available from this repository


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