School of Geography, Earth and Atmospheric Sciences - Research Publications
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ItemA field work report on newly discovered and documented megalithic jar sites in the Lao People’s Democratic Republic(Springer Science and Business Media LLC, 2023-12)Abstract Xieng Khouang and neighboring provinces in Central Laos are home to a vast megalithic landscape featuring large stone jars, discs, and imported boulders located in elevated positions. Sites were first noted in the late nineteenth century, with systematic recording commencing in the 1930s. Continuing on from the 2019 field survey by the Plain of Jars Archaeological Research Project, this paper presents the results of a 2020 survey across Xieng Khouang Province, Lao People’s Democratic Republic (PDR) which led to the documentation of 27 previously unreported megalithic sites, growing the Lao PDR Government database from 102 to 127 known jar sites, with 124 geo-located. In addition, a preliminary analysis of the known jar sites to date is conducted regarding distribution and jar characteristics providing a basis for further investigation.
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ItemThe human right to climate adaptation(Springer Science and Business Media LLC, )Abstract We demonstrate that a right to climate change adaptation exists in a bundle of pre-existing human rights norms. This existing right provides clear principles to guide the implementation of climate adaptation in ways that are equitable and effective, obliging States to, inter alia, prioritise those whose rights are most at risk from climate change; maximise the adaptive capacity of individuals; preserve territory to protect the sovereign rights of peoples; and ensure that adaptation practices themselves do not harm human rights. Human rights law requires that these obligations be fulfilled without discrimination on any grounds, including economic judgements about the cost effectiveness of adaptation in small or remote countries or communities.
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ItemMicroglial ferroptotic stress causes non-cell autonomous neuronal death(BMC, 2024-02-05)BACKGROUND: Ferroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requirement for iron. Although it protects against cancer and infection, ferroptosis is also implicated in causing neuronal death in degenerative diseases of the central nervous system (CNS). The precise role for ferroptosis in causing neuronal death is yet to be fully resolved. METHODS: To elucidate the role of ferroptosis in neuronal death we utilised co-culture and conditioned medium transfer experiments involving microglia, astrocytes and neurones. We ratified clinical significance of our cell culture findings via assessment of human CNS tissue from cases of the fatal, paralysing neurodegenerative condition of amyotrophic lateral sclerosis (ALS). We utilised the SOD1G37R mouse model of ALS and a CNS-permeant ferroptosis inhibitor to verify pharmacological significance in vivo. RESULTS: We found that sublethal ferroptotic stress selectively affecting microglia triggers an inflammatory cascade that results in non-cell autonomous neuronal death. Central to this cascade is the conversion of astrocytes to a neurotoxic state. We show that spinal cord tissue from human cases of ALS exhibits a signature of ferroptosis that encompasses atomic, molecular and biochemical features. Further, we show the molecular correlation between ferroptosis and neurotoxic astrocytes evident in human ALS-affected spinal cord is recapitulated in the SOD1G37R mouse model where treatment with a CNS-permeant ferroptosis inhibitor, CuII(atsm), ameliorated these markers and was neuroprotective. CONCLUSIONS: By showing that microglia responding to sublethal ferroptotic stress culminates in non-cell autonomous neuronal death, our results implicate microglial ferroptotic stress as a rectifiable cause of neuronal death in neurodegenerative disease. As ferroptosis is currently primarily regarded as an intrinsic cell death phenomenon, these results introduce an entirely new pathophysiological role for ferroptosis in disease.
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ItemThe distribution of fossil pollen and charcoal in stalagmites(CAMBRIDGE UNIV PRESS, 2023-05-16)Abstract Pollen preserved in caves provides a little-appreciated opportunity to study past vegetation and climate changes in regions where conventional wetland sediments are either unavailable, contain little organic matter, and/or are difficult to date accurately. Most palynology in caves has focused on clastic infill sediments, but pollen preserved in growing speleothems provides important new opportunities to develop vegetation and climatic records that can be dated accurately with radiometric methods. However, when pollen is present in speleothems, concentrations can vary by orders of magnitude, highlighting how little we know about the processes that transport pollen into caves and onto speleothem surfaces, and that determine the pollen's preservation probability. To explore these aspects of speleothem pollen taphonomy, we investigated the distribution of pollen and microscopic charcoal within several stalagmites from southwest Australia. We examined spatial patterns in pollen and charcoal preservation in order to distinguish whether observed gradients result from preservation or are products of systematic transport processes working along stalagmite surfaces. We find that pollen grains and charcoal fragments are located preferentially on the flanks of most stalagmites. This suggests that pollen grain and charcoal deposition on speleothems is influenced by transport and accumulation of detrital debris on growing surfaces. These insights will assist in future sampling campaigns focusing on speleothem pollen and charcoal contents.
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ItemNo Preview AvailableOn the relationship between mesoscale cellular convection and meteorological forcing: comparing the Southern Ocean against the North Pacific(Copernicus GmbH, 2023-12-20)Abstract. Marine atmospheric boundary layer (MABL) clouds cover vast areas over the ocean and have important radiative effects on the Earth's climate system. These radiative effects are known to be sensitive to the local organization, or structure, of the mesoscale cellular convection (MCC). A convolutional neural network model is used to identify the two idealized classes of MCC clouds, namely open and closed, over the Southern Ocean (SO) and Northwest Pacific (NP) from high-frequency geostationary Himawari-8 satellite observations. The results of the climatology show that MCC clouds are evenly distributed over the mid-latitude storm tracks for both hemispheres, with peaks poleward of the 40∘ latitude. Open-MCC clouds are more prevalent than closed MCC in both regions. An examination of the presumed meteorological forcing associated with open- and closed-MCC clouds is conducted to illustrate the influence of large-scale meteorological conditions. We establish the importance of the Kuroshio western boundary current in the spatial coverage of open and closed MCC across the NP, presumably through the supply of strong heat and moisture fluxes during marine cold-air outbreaks events. In regions where static stability is higher, we observe a more frequent occurrence of closed MCCs. This behavior contrasts markedly with that of open MCCs, whose formation and persistence are significantly influenced by the difference in temperature between the air and the sea surface. The occurrence frequency of closed MCC over the SO exhibits a significant diurnal cycle, while the diurnal cycle of closed MCC over the NP is less noticeable.
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ItemNo Preview AvailableEvidence for decreased copper associated with demyelination in the corpus callosum of cuprizone-treated mice(OXFORD UNIV PRESS, 2024-01-05)Demyelination within the central nervous system (CNS) is a significant feature of debilitating neurological diseases such as multiple sclerosis and administering the copper-selective chelatorcuprizone to mice is widely used to model demyelination in vivo. Conspicuous demyelination within the corpus callosum is generally attributed to cuprizone's ability to restrict copper availability in this vulnerable brain region. However, the small number of studies that have assessed copper in brain tissue from cuprizone-treated mice have produced seemingly conflicting outcomes, leaving the role of CNS copper availability in demyelination unresolved. Herein we describe our assessment of copper concentrations in brain samples from mice treated with cuprizone for 40 d. Importantly, we applied an inductively coupled plasma mass spectrometry methodology that enabled assessment of copper partitioned into soluble and insoluble fractions within distinct brain regions, including the corpus callosum. Our results show that cuprizone-induced demyelination in the corpus callosum was associated with decreased soluble copper in this brain region. Insoluble copper in the corpus callosum was unaffected, as were pools of soluble and insoluble copper in other brain regions. Treatment with the blood-brain barrier permeant copper compound CuII(atsm) increased brain copper levels and this was most pronounced in the soluble fraction of the corpus callosum. This effect was associated with significant mitigation of cuprizone-induced demyelination. These results provide support for the involvement of decreased CNS copper availability in demyelination in the cuprizone model. Relevance to human demyelinating disease is discussed.
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ItemNo Preview AvailablePotential to use free satellite imagery to retrieve the past bathymetry of large rivers(Elsevier BV, 2024-01-01)
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ItemNo Preview AvailableCurrent extent and future opportunities for living shorelines in Australia(ELSEVIER, 2024-03-20)Living shorelines aim to enhance the resilience of coastlines to hazards while simultaneously delivering co-benefits such as carbon sequestration. Despite the potential ecological and socio-economic benefits of living shorelines over conventional engineered coastal protection structures, application is limited globally. Australia has a long and diverse coastline that provides prime opportunities for living shorelines using beaches and dunes, vegetation, and biogenic reefs, which may be either natural ('soft' approach) or with an engineered structural component ('hybrid' approach). Published scientific studies, however, have indicated limited use of living shorelines for coastal protection in Australia. In response, we combined a national survey and interviews of coastal practitioners and a grey and peer-reviewed literature search to (1) identify barriers to living shoreline implementation; and (2) create a database of living shoreline projects in Australia based on sources other than scientific literature. Projects included were those that had either a primary or secondary goal of protection of coastal assets from erosion and/or flooding. We identified 138 living shoreline projects in Australia through the means sampled starting in 1970; with the number of projects increasing through time particularly since 2000. Over half of the total projects (59 %) were considered to be successful according to their initial stated objective (i.e., reducing hazard risk) and 18 % of projects could not be assessed for their success based on the information available. Seventy percent of projects received formal or informal monitoring. Even in the absence of peer-reviewed support for living shoreline construction in Australia, we discovered local and regional increases in their use. This suggests that coastal practitioners are learning on-the-ground, however more generally it was stated that few examples of living shorelines are being made available, suggesting a barrier in information sharing among agencies at a broader scale. A database of living shoreline projects can increase knowledge among practitioners globally to develop best practice that informs technical guidelines for different approaches and helps focus attention on areas for further research.
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ItemNo Preview AvailableWorking with care: embodying feminist care ethics in regional coworking spaces(PERGAMON-ELSEVIER SCIENCE LTD, 2023-03)
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ItemNo Preview AvailableFreshwater mollusc sclerochronology: Trends, challenges, and future directions(Elsevier BV, 2023-12-01)