Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes
AuthorMcNamara, HC; Frawley, HC; Donoghue, JF; Readman, E; Healey, M; Ellett, L; Reddington, C; Hicks, LJ; Harlow, K; Rogers, PAW; ...
Source TitleFrontiers in Reproductive Health
PublisherFrontiers Media SA
University of Melbourne Author/sDonoghue, Jacqueline; Frawley, Helena; Rogers, Peter; Reddington, Charlotte
AffiliationObstetrics and Gynaecology
Melbourne School of Health Sciences
Document TypeJournal Article
CitationsMcNamara, H. C., Frawley, H. C., Donoghue, J. F., Readman, E., Healey, M., Ellett, L., Reddington, C., Hicks, L. J., Harlow, K., Rogers, P. A. W. & Cheng, C. (2021). Peripheral, Central, and Cross Sensitization in Endometriosis-Associated Pain and Comorbid Pain Syndromes. Frontiers in Reproductive Health, 3, pp.729642-. https://doi.org/10.3389/frph.2021.729642.
Access StatusOpen Access
Endometriosis-associated pain and the mechanisms responsible for its initiation and persistence are complex and difficult to treat. Endometriosis-associated pain is experienced as dysmenorrhea, cyclical pain related to organ function including dysuria, dyschezia and dyspareunia, and persistent pelvic pain. Pain symptomatology correlates poorly with the extent of macroscopic disease. In addition to the local effects of disease, endometriosis-associated pain develops as a product of peripheral sensitization, central sensitization and cross sensitization. Endometriosis-associated pain is further contributed to by comorbid pain conditions, such as bladder pain syndrome, irritable bowel syndrome, abdomino-pelvic myalgia and vulvodynia. This article will review endometriosis-associated pain, its mechanisms, and its comorbid pain syndromes with a view to aiding the clinician in navigating the literature and terminology of pain and pain syndromes. Limitations of our current understanding of endometriosis-associated pain will be acknowledged. Where possible, commonalities in pain mechanisms between endometriosis-associated pain and comorbid pain syndromes will be highlighted.
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References