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dc.contributor.authorMartin, K
dc.contributor.authorTan, S-J
dc.contributor.authorToussaint, ND
dc.date.accessioned2021-10-25T04:11:18Z
dc.date.available2021-10-25T04:11:18Z
dc.date.issued2021-09-22
dc.identifier.citationMartin, K., Tan, S. -J. & Toussaint, N. D. (2021). Total Body Sodium Balance in Chronic Kidney Disease. INTERNATIONAL JOURNAL OF NEPHROLOGY, 2021, https://doi.org/10.1155/2021/7562357.
dc.identifier.issn2090-214X
dc.identifier.urihttp://hdl.handle.net/11343/289801
dc.description.abstractExcess sodium intake is a leading but modifiable risk factor for mortality, with implications on hypertension, inflammation, cardiovascular disease, and chronic kidney disease (CKD). This review will focus mainly on the limitations of current measurement methods of sodium balance particularly in patients with CKD who have complex sodium physiology. The suboptimal accuracy of sodium intake and excretion measurement is seemingly more marked with the evolving understanding of tissue (skin and muscle) sodium. Tissue sodium represents an extrarenal influence on sodium homeostasis with demonstrated clinical associations of hypertension and inflammation. Measurement of tissue sodium has been largely unexplored in patients with CKD. Development and adoption of more comprehensive and dynamic assessment of body sodium balance is needed to better understand sodium physiology in the human body and explore therapeutic strategies to improve the clinical outcomes in the CKD population.
dc.languageEnglish
dc.publisherHINDAWI LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleTotal Body Sodium Balance in Chronic Kidney Disease
dc.typeJournal Article
dc.identifier.doi10.1155/2021/7562357
melbourne.affiliation.departmentMedicine Dentistry & Health Sciences
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleInternational Journal of Nephrology
melbourne.source.volume2021
dc.rights.licenseCC BY
melbourne.elementsid1597629
melbourne.contributor.authorMartin, Kylie
dc.identifier.eissn2090-2158
melbourne.accessrightsOpen Access


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