Show simple item record

dc.contributor.authorShen, AJJ
dc.contributor.authorKing, J
dc.contributor.authorColman, PG
dc.contributor.authorYates, CJ
dc.date.accessioned2021-10-25T23:57:35Z
dc.date.available2021-10-25T23:57:35Z
dc.date.issued2021-09
dc.identifier.citationShen, A. J. J., King, J., Colman, P. G. & Yates, C. J. (2021). Diagnosis and management of adrenocorticotropic hormone-secreting pituitary carcinoma: a case report and review of the literature. Future Rare Diseases, 1 (3), pp.frd13-. https://doi.org/10.2217/frd-2021-0007.
dc.identifier.issn2399-5262
dc.identifier.urihttp://hdl.handle.net/11343/289877
dc.description.abstractAdrenocorticotropic hormone (ACTH)-secreting pituitary carcinomas (PC) are rare. The natural history and management of these carcinomas are poorly understood. We conducted a literature review using The MEDLINE database, including the search terms; ‘ACTH’ and ‘pituitary carcinoma’. We also describe in detail a case of ACTH-secreting PC. A total of 61 case reports were reviewed. Median age of diagnosis was 45 years (IQR: 34–54). Metastases to multiple organs were common (61%). Adjuvant therapy especially radiotherapy (78%), temozolomide (34%) and other medical therapy (29%) were frequently employed. The mortality was 53% with a median time to death from diagnosis of 1 year (IQR: 1–3). In conclusion, ACTH-secreting PC are associated with high mortality and a multidisciplinary team approach is recommended for optimal care due to the emerging modalities with possible efficacy.
dc.languageen
dc.publisherFuture Medicine Ltd
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleDiagnosis and management of adrenocorticotropic hormone-secreting pituitary carcinoma: a case report and review of the literature
dc.typeJournal Article
dc.identifier.doi10.2217/frd-2021-0007
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleFuture Rare Diseases
melbourne.source.volume1
melbourne.source.issue3
melbourne.source.pagesfrd13-
dc.rights.licenseCC BY NC ND
melbourne.elementsid1592381
melbourne.contributor.authorYates, Christopher
melbourne.contributor.authorColman, Peter
dc.identifier.eissn2399-5270
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record