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    The galanin-3 receptor antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats

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    Author
    Ash, BL; Zanatta, SD; Williams, SJ; Lawrence, AJ; Djouma, E
    Date
    2011-01-17
    Source Title
    REGULATORY PEPTIDES
    Publisher
    ELSEVIER SCIENCE BV
    University of Melbourne Author/s
    Williams, Spencer; Lawrence, Andrew; ZANATTA, SHANNON
    Affiliation
    Chemistry
    Metadata
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    Document Type
    Journal Article
    Citations
    Ash, B. L., Zanatta, S. D., Williams, S. J., Lawrence, A. J. & Djouma, E. (2011). The galanin-3 receptor antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats. REGULATORY PEPTIDES, 166 (1-3), pp.59-67. https://doi.org/10.1016/j.regpep.2010.08.009.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/29006
    DOI
    10.1016/j.regpep.2010.08.009
    Description

    C1 - Journal Articles Refereed

    Abstract
    BACKGROUND/OBJECTIVE: The galanin-3 receptor (GALR3) subtype has been identified as having a role in both feeding behaviour and the regulation of emotional states including anxiety. Despite the evidence for an association between galanin and alcohol, the current study is the first to explore the direct role of GALR3 in this context. The present study investigated the potential of the novel selective GALR3 antagonist, SNAP 37889, to reduce anxiety-like behaviour and voluntary ethanol consumption in the iP (alcohol-preferring) rat. This was achieved through a number of behavioural paradigms testing for anxiety, along with the operant self-administration model. RESULTS: Overall, male iP rats treated with SNAP 37889 at a dose of 30 mg/kg (i.p.) did not show altered locomotor activity or changes in anxiety-like behaviour in the elevated plus maze or light-dark paradigms. Treatment with SNAP 37889 (30 mg/kg, i.p.) reduced operant responding for solutions containing ethanol, sucrose and saccharin. Collectively, results from the current study showed that SNAP 37889 (30 mg/kg, i.p.) is effective in reducing operant responding for ethanol, independent of a sedative effect. CONCLUSIONS: These findings provide evidence that GALR3 antagonism reduces alcohol consumption and further suggest that GALR3 may be implicated in the rewarding effects of natural and drug reinforcers.
    Keywords
    Medicinal and Biomolecular Chemistry not elsewhere classified; Human Pharmaceutical Treatments (e.g. Antibiotics)

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