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dc.contributor.authorPillarisetti, N
dc.contributor.authorWilliamson, E
dc.contributor.authorLinnane, B
dc.contributor.authorSkoric, B
dc.contributor.authorRobertson, CF
dc.contributor.authorRobinson, P
dc.contributor.authorMassie, J
dc.contributor.authorHall, GL
dc.contributor.authorSly, P
dc.contributor.authorStick, S
dc.contributor.authorRanganathan, S
dc.date.available2014-05-21T22:29:00Z
dc.date.issued2011-07-01
dc.identifierpii: 201011-1892OC
dc.identifier.citationPillarisetti, N., Williamson, E., Linnane, B., Skoric, B., Robertson, C. F., Robinson, P., Massie, J., Hall, G. L., Sly, P., Stick, S. & Ranganathan, S. (2011). Infection, Inflammation, and Lung Function Decline in Infants with Cystic Fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 184 (1), pp.75-81. https://doi.org/10.1164/rccm.201011-1892OC.
dc.identifier.issn1073-449X
dc.identifier.urihttp://hdl.handle.net/11343/29065
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractRATIONALE: Better understanding of evolution of lung function in infants with cystic fibrosis (CF) and its association with pulmonary inflammation and infection is crucial in informing both early intervention studies aimed at limiting lung damage and the role of lung function as outcomes in such studies. OBJECTIVES: To describe longitudinal change in lung function in infants with CF and its association with pulmonary infection and inflammation. METHODS: Infants diagnosed after newborn screening or clinical presentation were recruited prospectively. FVC, forced expiratory volume in 0.5 seconds (FEV(0.5)), and forced expiratory flows at 75% of exhaled vital capacity (FEF(75)) were measured using the raised-volume technique, and z-scores were calculated from published reference equations. Pulmonary infection and inflammation were measured in bronchoalveolar lavage within 48 hours of lung function testing. MEASUREMENTS AND MAIN RESULTS: Thirty-seven infants had at least two successful repeat lung function measurements. Mean (SD) z-scores for FVC were -0.8 (1.0), -0.9 (1.1), and -1.7 (1.2) when measured at the first visit, 1-year visit, or 2-year visit, respectively. Mean (SD) z-scores for FEV(0.5) were -1.4 (1.2), -2.4 (1.1), and -4.3 (1.6), respectively. In those infants in whom free neutrophil elastase was detected, FVC z-scores were 0.81 lower (P=0.003), and FEV(0.5) z-scores 0.96 lower (P=0.001), respectively. Significantly greater decline in FEV(0.5) z-scores occurred in those infected with Staphylococcus aureus (P=0.018) or Pseudomonas aeruginosa (P=0.021). CONCLUSIONS: In infants with CF, pulmonary inflammation is associated with lower lung function, whereas pulmonary infection is associated with a greater rate of decline in lung function. Strategies targeting pulmonary inflammation and infection are required to prevent early decline in lung function in infants with CF.
dc.languageEnglish
dc.publisherAMER THORACIC SOC
dc.subjectRespiratory Diseases; Paediatrics; Respiratory System and Diseases (incl. Asthma); Child Health
dc.titleInfection, Inflammation, and Lung Function Decline in Infants with Cystic Fibrosis
dc.typeJournal Article
dc.identifier.doi10.1164/rccm.201011-1892OC
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleAMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
melbourne.source.volume184
melbourne.source.issue1
melbourne.source.pages75-81
dc.research.codefor110203
dc.research.codefor111403
dc.research.codeseo2008920115
dc.research.codeseo2008920501
melbourne.publicationid168450
melbourne.elementsid337997
melbourne.contributor.authorWILLIAMSON, ELIZABETH
melbourne.contributor.authorRobertson, Colin
melbourne.contributor.authorRobins-Browne, Roy
melbourne.contributor.authorRobinson, Philip
melbourne.contributor.authorMassie, Richard
melbourne.contributor.authorRanganathan, Sarath
dc.identifier.eissn1535-4970
melbourne.conference.locationUnited States
melbourne.accessrightsThis item is currently not available from this repository


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