Plasmodium falciparum: Genetic and immunogenic characterisation of the rhoptry neck protein PfRON4
Author
Morahan, BJ; Sallmann, GB; Huestis, R; Dubljevic, V; Waller, KLDate
2009-08-01Source Title
EXPERIMENTAL PARASITOLOGYPublisher
ACADEMIC PRESS INC ELSEVIER SCIENCEUniversity of Melbourne Author/s
Waller, KarenaAffiliation
Microbiology And ImmunologyMetadata
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Journal ArticleCitations
Morahan, B. J., Sallmann, G. B., Huestis, R., Dubljevic, V. & Waller, K. L. (2009). Plasmodium falciparum: Genetic and immunogenic characterisation of the rhoptry neck protein PfRON4. EXPERIMENTAL PARASITOLOGY, 122 (4), pp.280-288. https://doi.org/10.1016/j.exppara.2009.04.013.Access Status
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C1 - Journal Articles Refereed
Abstract
The Apicomplexan parasites Toxoplasma and Plasmodium, respectively, cause toxoplasmosis and malaria in humans and although they invade different host cells they share largely conserved invasion mechanisms. Plasmodium falciparum merozoite invasion of red blood cells results from a series of co-ordinated events that comprise attachment of the merozoite, its re-orientation, release of the contents of the invasion-related apical organelles (the rhoptries and micronemes) followed by active propulsion of the merozoite into the cell via an actin-myosin motor. During this process, a tight junction between the parasite and red blood cell plasma membranes is formed and recent studies have identified rhoptry neck proteins, including PfRON4, that are specifically associated with the tight junction during invasion. Here, we report the structure of the gene that encodes PfRON4 and its apparent limited diversity amongst geographically diverse P. falciparum isolates. We also report that PfRON4 protein sequences elicit immunogenic responses in natural human malaria infections.
Keywords
Cellular Immunology; Immune System and AllergyExport Reference in RIS Format
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