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dc.contributor.authorMorahan, BJ
dc.contributor.authorSallmann, GB
dc.contributor.authorHuestis, R
dc.contributor.authorDubljevic, V
dc.contributor.authorWaller, KL
dc.date.available2014-05-21T22:30:10Z
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.available2009-04-29
dc.date.issued2009-08-01
dc.identifierpii: S0014-4894(09)00122-2
dc.identifier.citationMorahan, B. J., Sallmann, G. B., Huestis, R., Dubljevic, V. & Waller, K. L. (2009). Plasmodium falciparum: Genetic and immunogenic characterisation of the rhoptry neck protein PfRON4. EXPERIMENTAL PARASITOLOGY, 122 (4), pp.280-288. https://doi.org/10.1016/j.exppara.2009.04.013.
dc.identifier.issn0014-4894
dc.identifier.urihttp://hdl.handle.net/11343/29077
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractThe Apicomplexan parasites Toxoplasma and Plasmodium, respectively, cause toxoplasmosis and malaria in humans and although they invade different host cells they share largely conserved invasion mechanisms. Plasmodium falciparum merozoite invasion of red blood cells results from a series of co-ordinated events that comprise attachment of the merozoite, its re-orientation, release of the contents of the invasion-related apical organelles (the rhoptries and micronemes) followed by active propulsion of the merozoite into the cell via an actin-myosin motor. During this process, a tight junction between the parasite and red blood cell plasma membranes is formed and recent studies have identified rhoptry neck proteins, including PfRON4, that are specifically associated with the tight junction during invasion. Here, we report the structure of the gene that encodes PfRON4 and its apparent limited diversity amongst geographically diverse P. falciparum isolates. We also report that PfRON4 protein sequences elicit immunogenic responses in natural human malaria infections.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.subjectCellular Immunology; Immune System and Allergy
dc.titlePlasmodium falciparum: Genetic and immunogenic characterisation of the rhoptry neck protein PfRON4
dc.typeJournal Article
dc.identifier.doi10.1016/j.exppara.2009.04.013
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleEXPERIMENTAL PARASITOLOGY
melbourne.source.volume122
melbourne.source.issue4
melbourne.source.pages280-288
dc.research.codefor110704
dc.research.codeseo2008920108
melbourne.publicationid157582
melbourne.elementsid331056
melbourne.contributor.authorWaller, Karena
dc.identifier.eissn1090-2449
pubs.acceptance.date2009-04-29
melbourne.accessrightsThis item is currently not available from this repository


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