Genetics - Research Publications
Now showing items 1-10 of 10
JNK signaling is needed to tolerate chromosomal instability
(LANDES BIOSCIENCE, 2014-02-27)
Chromosomal instability (CIN), as a common feature of tumors, represents a potential therapeutic target if ways can be found to specifically cause apoptosis in unstably dividing cells. We have previously shown that if ...
A Screen for Selective Killing of Cells with Chromosomal Instability Induced by a Spindle Checkpoint Defect
(PUBLIC LIBRARY SCIENCE, 2012)
Background: The spindle assembly checkpoint is crucial for the maintenance of a stable chromosome number. Defects in the checkpoint lead to Chromosomal INstability (CIN), which is linked to the progression of tumors with ...
Association between Three Mutations, F1565C, V1023G and S996P, in the Voltage-Sensitive Sodium Channel Gene and Knockdown Resistance in Aedes aegypti from Yogyakarta, Indonesia
Mutations in the voltage-sensitive sodium channel gene (Vssc) have been identified in Aedes aegypti and some have been associated with pyrethroid insecticide resistance. Whether these mutations cause resistance, alone or ...
Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transporter Subfamily A Protein
(PUBLIC LIBRARY SCIENCE, 2015-11-01)
The use of conventional chemical insecticides and bacterial toxins to control lepidopteran pests of global agriculture has imposed significant selection pressure leading to the rapid evolution of insecticide resistance. ...
Expression of insect alpha 6-like nicotinic acetylcholine receptors in Drosophila melanogaster highlights a high level of conservation of the receptor:spinosyn interaction
(PERGAMON-ELSEVIER SCIENCE LTD, 2015-09-01)
Insecticide research has often relied on model species for elucidating the resistance mechanisms present in the targeted pests. The accuracy and applicability of extrapolations of these laboratory findings to field conditions ...
The Wiggle Index: An Open Source Bioassay to Assess Sub-Lethal Insecticide Response in Drosophila melanogaster
(PUBLIC LIBRARY SCIENCE, 2015-12-18)
Toxicological assays measuring mortality are routinely used to describe insecticide response, but sub-lethal exposures to insecticides can select for resistance and yield additional biological information describing the ...
In vivo imaging and tracking of individual nanodiamonds in drosophila melanogaster embryos
(OPTICAL SOC AMER, 2014-04-01)
In this work, we incorporate and image individual fluorescent nanodiamonds in the powerful genetic model system Drosophila melanogaster. Fluorescence correlation spectroscopy and wide-field imaging techniques are applied ...
FILAMENTOUS FLOWER controls lateral organ development by acting as both an activator and a repressor
BACKGROUND: The YABBY (YAB) family of transcription factors participate in a diverse range of processes that include leaf and floral patterning, organ growth, and the control of shoot apical meristem organisation and ...
Inconsistent effects of developmental temperature acclimation on low-temperature performance and metabolism in Drosophila melanogaster
(EVOLUTIONARY ECOLOGY LTD, 2012-01-01)