Management of Early Node-Positive Breast Cancer in Australia: A Multicentre Study
AuthorGannan, E; Khoo, J; Nightingale, S; Suhardja, TS; Lippey, J; Keane, H; Tan, KJ; Clouston, D; Gorelik, A; Mann, GB
Source TitleThe Breast Journal
University of Melbourne Author/sGorelik, Alexandra; Henderson, Michael; Mann, Gregory; TAN, KIAN; Nightingale, Sophie; Lippey, Jocelyn
AffiliationMelbourne Graduate School of Education
Surgery (St Vincent's)
Surgery (Western Health)
Document TypeJournal Article
CitationsGannan, E., Khoo, J., Nightingale, S., Suhardja, T. S., Lippey, J., Keane, H., Tan, K. J., Clouston, D., Gorelik, A. & Mann, G. B. (2016). Management of Early Node-Positive Breast Cancer in Australia: A Multicentre Study. BREAST JOURNAL, 22 (4), pp.413-419. https://doi.org/10.1111/tbj.12595.
Access StatusOpen Access
To examine practice patterns for breast cancer patients with limited sentinel node (SN) disease in light of the ACOSOG Z0011 results. Retrospective analysis of patients with T1-2 breast cancer and positive sentinel lymph node biopsy (SLNB) admitted between January 2009 and December 2012. Patient demographics, tumor characteristics, and treatments were recorded. Eight hundred positive SLNBs were identified. A total of 452 (56.5%) proceeded to completion axillary lymph node dissection (cALND). cALND rate decreased from 65.1% to 49.7% from 2009-2010 to 2011-2012. cALND was performed for micrometastasis or isolated tumor cells in 39.3% in 2009-2010 and 22.2% in 2011-2012, whereas for macrometastases the rates were 83.1% and 68.6%, respectively. cALND rates diminished for both Z0011-eligible and -ineligible patients. The ACOSOG Z0011 trial presentation and publication coincided with a reduction in cALND for breast cancer with limited nodal disease. There appears equipoise regarding management of macrometastatic SN disease.
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