Bone turnover markers and bone mineral density in healthy mother–daughter pairs from South India
Loading...
Download
Associated Records
Authors
File Licence
Editors
Date
2016-11-01
Source Title
Clinical Endocrinology
Journal Title
Journal ISSN
Volume Title
Publisher
WILEY-BLACKWELL
Melbourne Authors
Affiliation
Medicine Dentistry & Health Sciences
Document Type
Journal Article
Subject Code
Citation
Shetty, S., Kapoor, N., Dian Bondu, J., Antonisamy, B., Thomas, N. & Paul, T. V. (2016). Bone turnover markers and bone mineral density in healthy mother–daughter pairs from South India. Clinical Endocrinology, 85 (5), pp.725-732. https://doi.org/10.1111/cen.13173.
Access Status
Open Access
Access URL
Open Access URL
Open Access at PMC
Linked Resource URL
NHMRC Grant Code
ARC Grant Code
Description
Abstract
UNLABELLED: Bone turnover markers (BTMs) provide important insights into the dynamics of bone remodelling and are subjected to preanalytical and ethnic variations in addition to influence of genetic and environmental factors. AIM/OBJECTIVES: To derive ethnicity specific reference range for BTMs and to study their correlation with Bone Mineral Density (BMD) in a cohort of healthy postmenopausal women and their premenopausal daughters and to look at the impact of maternal bone mineral status on daughters bone health. MATERIAL AND METHODS: This community based cross sectional study included 300 subjects (150 mother-daughter pairs). Demographic details were collected. Fasting blood and a second void morning urine samples were obtained for measurement of BTMs (sCTX, sPTNP1, sOC and urine DPD respectively) and bone mineral parameters. BMD was measured by DXA scan. RESULTS: Osteoporosis was seen in 44·7% of the postmenopausal women. Ethnicity specific reference ranges of BTMs were derived for the study population. Significant inverse correlation was found between all BTMs (except urine DPD) and BMD(P < 0·05). Daughters of mothers with osteoporosis at spine and femoral neck had lower BMD, compared to daughters of mothers without osteoporosis(P = 0·03 & 0·05). CONCLUSION: Apart from deriving the ethnicity specific reference range for BTMs and finding a significant inverse correlation between BTM and BMD, this study found significantly lower BMD in daughters of mothers with osteoporosis at spine and femoral neck implicating the probable interplay of genetic, epigenetic and similar environmental factors.