Genetics - Theses
Now showing items 1-10 of 45
In vivo functional characterization of nicotinic acetylcholine receptors in Drosophila melanogaster
Nicotinic acetylcholine receptors (nAChRs) are responsible for fast excitatory synaptic transmission in insect central nervous system. Their role as targets for commercial insecticides have resulted in extensive studies ...
Population genomics and transcriptomics in the cotton bollworm, Helicoverpa armigera
Helicoverpa armigera is an agricultural pest that causes billions of dollars' worth of damage each year. As H. armigera has evolved resistance to insecticides, an understanding of resistance genes will provide useful ...
Understanding aphids: transcriptomics, molecular evolution and pest control
Aphids exhibit fascinating biological features including parthenogenesis, symbiosis, altruism and host-plant preference; all of which would be better understood if genetic tools and molecular biological techniques were ...
Identifying downstream targets of FILAMENTOUS FLOWER, a YABBY transcription factor that promotes organ polarity and lateral growth in Arabidopsis
Angiosperm leaves are typically polar structures with a distinct arrangement of cell types along the adaxial-abaxial (upper-lower) axis. Studies of leaf development in the model dicot plant Arabidopsis thaliana have shown ...
The genetic basis of resistance to the Ryanodine Receptor modulator chlorantraniliprole in Drosophila melanogaster
The development of synthetic insecticides in the mid 20th century lead to a revolution in pest control. However, issues with environmental toxicity, adverse human exposure and insecticide resistance have meant new safer ...
The significance of low level mosaicism in Fragile X Syndrome.
Fragile X Syndrome (FXS) is the most common single disorder associated with intellectual disability (ID) and autism spectrum disorder (ASD). FXS is fundamentally caused by a trinucleotide CGG sequence repeat expansion ...
A genome-wide analysis of carbon catabolite repression in Schizosaccharomyces pombe
The process by which eukaryotic microorganisms preferentially utilise glucose as a carbon source is coordinated by a network of sensory and signalling pathways, which converge at the transcriptional level to control the ...
The evolution of pathogenicity and isolate variation in Talaromyces marneffei
The opportunistic fungal pathogen of humans, Talaromyces marneffei, is one of very few pathogens in an order of over a thousand species and the only species that has the capacity to switch between two morphologically ...
Probing insecticide biology using Drosophila melanogaster
Insecticides are often used to control insect pests, but resistance to these chemicals arises quickly, leading to agricultural losses and public health concerns. Understanding how insects cope with insecticides is necessary ...
The genomic basis of climate and host adaptation
Many species are currently threatened by the direct and indirect effects of anthropogenically driven climate change. The elevation of global temperatures and increase in variability in both temperature and precipitation ...