Three-dimensional neural cultures produce networks that mimic native brain activity

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    Author
    Bourke, JL; Quigley, AF; Duchi, S; O'Connell, CD; Crook, JM; Wallace, GG; Cook, MJ; Kapsa, RMI
    Date
    2018-02-01
    Source Title
    Journal of Tissue Engineering and Regenerative Medicine
    Publisher
    WILEY
    University of Melbourne Author/s
    Duchi, Serena; Bourke, Justin; Quigley, Anita; Crook, Jeremy; O'Connell, Cathal; Wallace, Gordon; Cook, Mark; Kapsa, Robert
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Biomedical Engineering
    Medicine (St Vincent's)
    Surgery (St Vincent's)
    Metadata
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    Document Type
    Journal Article
    Citations
    Bourke, J. L., Quigley, A. F., Duchi, S., O'Connell, C. D., Crook, J. M., Wallace, G. G., Cook, M. J. & Kapsa, R. M. I. (2018). Three-dimensional neural cultures produce networks that mimic native brain activity. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 12 (2), pp.490-493. https://doi.org/10.1002/term.2508.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/294029
    DOI
    10.1002/term.2508
    Abstract
    Development of brain function is critically dependent on neuronal networks organized through three dimensions. Culture of central nervous system neurons has traditionally been limited to two dimensions, restricting growth patterns and network formation to a single plane. Here, with the use of multichannel extracellular microelectrode arrays, we demonstrate that neurons cultured in a true three-dimensional environment recapitulate native neuronal network formation and produce functional outcomes more akin to in vivo neuronal network activity.

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