School of Chemistry - Theses
Now showing items 1-10 of 217
Design and synthesis of chemical tools for studies of carbohydrate active enzymes
Glycoside hydrolases (GH) are enzymes that catalyse the hydrolysis of glycosidic linkages. They are classified into over 150 families based on their primary amino acid sequence. Family GH99 endo-α-1,2-mannosidases/endo-α ...
It’s hip to be square: a cyclobutene diester approach to alkyl citrate natural products
This thesis features an enatiospecfic synthesis of a key alkyl citrate retron that was leveraged in the total syntheses of squalene synthase inhibitors (-)-CJ-13,982, (-)-CJ-13,981 and (-)-L-731,120 (featured in Org. Let. ...
Phytoextraction of mercury (Hg) and gold (Au) from contaminated mine tailings and biosolids
The present study is based on a long-term goal of using phytotechnologies to rehabilitate Hg-contaminated substrates like mine tailings and biosolids with the additional value of recovering Au residues. To address this ...
Amide assembly through Ag(I) promoted reaction of thioamides bearing self cleaving auxiliaries
Synthesis of amide bonds is an important issue in organic chemistry but is often overlooked as a contemporary challenge. Existing methods are reaching their limits and new chemical approaches are being developed. The Ag(I) ...
Use of thioamides in peptide synthesis: strategies for ring expansion and peptide ligation at asparagine
Peptide therapeutics are used directly or as carriers of cytotoxic agents and radioisotopes to specifically target diseased cells. The synthesis of peptides is one of the most important issues in organic chemistry. We have ...
Zirconium and copper immunoPET imaging agents for the diagnosis of cancer
Positron emission tomography (PET) is a medical diagnostic imaging technique that is particularly useful in cancer diagnostics. In addition to tumour burden assessment, the technology can also provide molecular information, ...
Mechanisms governing plastron retention and the implications for antifouling technologies
Marine fouling refers to the unwanted settlement of biotic and abiotic dissolved compounds, microorganisms, plants, and animals upon surfaces immersed in seawater. Biofouling presents considerable economic pressure upon ...
Functionalized mesoporous metal oxide spheres as catalysts for efficient conversion of carbohydrates into 5-hydroxymethylfurfural
Fossil fuels currently provide more than 90% of global energy needs and feedstocks for the chemical industry. One of the most critical challenges facing mankind is reducing emissions of carbon dioxide. Biomass is a globally ...
Synthesis and evaluation of Oncrasin based radiotracers for oncology
KRAS mutation status in cancer is an important contributing factor to development of cancerous tissue, with the mutation occurring in an estimated 1/3 of all cases of cancer, resulting in an aggressive phenotype. Development ...
In-situ monitored growth of semiconductor nanoclusters and nanoparticles
The thesis question deals with the formation process of semiconductor quantum dots. It includes the diffusion-controlled perovskite synthesis in microfluidic devices and the detection of superstructures through oriented-attachment ...