Glycoside hydrolases (GH) are enzymes that catalyse the hydrolysis of glycosidic linkages. They are classified into over 150 families based on their primary amino acid sequence. Family GH99 endo-α-1,2-mannosidases/endo-α ...

This thesis features an enatiospecfic synthesis of a key alkyl citrate retron that was leveraged in the total syntheses of squalene synthase inhibitors (-)-CJ-13,982, (-)-CJ-13,981 and (-)-L-731,120 (featured in Org. Let. ...

The present study is based on a long-term goal of using phytotechnologies to rehabilitate Hg-contaminated substrates like mine tailings and biosolids with the additional value of recovering Au residues. To address this ...

Synthesis of amide bonds is an important issue in organic chemistry but is often overlooked as a contemporary challenge. Existing methods are reaching their limits and new chemical approaches are being developed. The Ag(I) ...

Peptide therapeutics are used directly or as carriers of cytotoxic agents and radioisotopes to specifically target diseased cells. The synthesis of peptides is one of the most important issues in organic chemistry. We have ...

Positron emission tomography (PET) is a medical diagnostic imaging technique that is particularly useful in cancer diagnostics. In addition to tumour burden assessment, the technology can also provide molecular information, ...

Marine fouling refers to the unwanted settlement of biotic and abiotic dissolved compounds, microorganisms, plants, and animals upon surfaces immersed in seawater. Biofouling presents considerable economic pressure upon ...

Fossil fuels currently provide more than 90% of global energy needs and feedstocks for the chemical industry. One of the most critical challenges facing mankind is reducing emissions of carbon dioxide. Biomass is a globally ...

KRAS mutation status in cancer is an important contributing factor to development of cancerous tissue, with the mutation occurring in an estimated 1/3 of all cases of cancer, resulting in an aggressive phenotype. Development ...

The thesis question deals with the formation process of semiconductor quantum dots. It includes the diffusion-controlled perovskite synthesis in microfluidic devices and the detection of superstructures through oriented-attachment ...