It is commonly believed that high eye pressure induced retinal ganglion cell injury is irreversible in glaucoma, however current studies suggest otherwise. This thesis developed a glaucoma model in mice to demonstrate that ...

Studies have repeatedly shown that physiological aging impacts contextual spatial vision in central vision. Some visual functions are different between foveal and non-foveal vision and we have limited understanding of ...

Although a well-regulated blood supply is important for healthy neural function, the mechanism by which this occurs is still disputed; some studies charge this physiological response solely to the muscular arterioles, ...

The prevalence of myopia and its associated sight threatening pathology is anticipated to increase, making high myopia a global health concern, especially in our ageing population. Although pathological sequelae and visual ...

Visual information is transmitted from the retina to the primary visual cortex (V1) through the lateral geniculate nucleus (LGN). At each stage along this visual pathway, the receptive field properties of neurons are ...

Even when we stare intently at an object, our eyes are in constant motion due to small, involuntary eye movements. Despite this, we do not perceive a jittery world as the visual system is able to compensate for the motion ...

This thesis shows that amyloid beta found in the brain is also present in the retina of a murine model of Alzheimer’s disease. By applying non-invasive retinal techniques, we show that neuronal structural and functional ...

Most modern skills, like driving a car, playing video games or reading a book, are relatively recent occurrences in human history and have presumably no specific hard-wired neural pathways. Instead, they piggyback on neural ...

One of the main concerns of visual neuroscience is to understand how information is processed by the neural circuits in the visual system. Since the historic experiments of Hubel and Wiesel, many more aspects of visual ...

Healthy ageing alters contextual spatial interactions such as centre surround contrast suppression and spatial suppression of motion discrimination. However, the exact neural mechanisms that underlie age related changes ...