Characterising receptive fields (RFs) in the primary visual cortex (V1) is central to understanding how neurons and neural circuits process visual information. The goal of this thesis is to systemically compare the two ...

Purpose: Ageing is recognised as a major risk factor for several ocular pathologies, including dry eye disease. The aim of this thesis was to characterise the specific effect of ageing on key ocular surface parameters, in ...

Diabetic retinopathy (DR) is a significant cause of vision impairment worldwide, and it is projected to incur a rising global disease burden. Although the pathophysiology of diabetic retinopathy had been historically ...

In between attacks, people with migraine report experiencing both visual discomfort and visual illusions induced by stationary high contrast striped patterns. Since both visual illusion and discomfort have been assessed ...

It is commonly believed that high eye pressure induced retinal ganglion cell injury is irreversible in glaucoma, however current studies suggest otherwise. This thesis developed a glaucoma model in mice to demonstrate that ...

Studies have repeatedly shown that physiological aging impacts contextual spatial vision in central vision. Some visual functions are different between foveal and non-foveal vision and we have limited understanding of ...

Although a well-regulated blood supply is important for healthy neural function, the mechanism by which this occurs is still disputed; some studies charge this physiological response solely to the muscular arterioles, ...

The prevalence of myopia and its associated sight threatening pathology is anticipated to increase, making high myopia a global health concern, especially in our ageing population. Although pathological sequelae and visual ...

Visual information is transmitted from the retina to the primary visual cortex (V1) through the lateral geniculate nucleus (LGN). At each stage along this visual pathway, the receptive field properties of neurons are ...

Even when we stare intently at an object, our eyes are in constant motion due to small, involuntary eye movements. Despite this, we do not perceive a jittery world as the visual system is able to compensate for the motion ...