Optometry and Vision Sciences - Theses
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Retinal neurovascular coupling in streptozotocin diabetic rats
Diabetic retinopathy (DR) is a significant cause of vision impairment worldwide, and it is projected to incur a rising global disease burden. Although the pathophysiology of diabetic retinopathy had been historically ...
Illusory motion perception in migraine
In between attacks, people with migraine report experiencing both visual discomfort and visual illusions induced by stationary high contrast striped patterns. Since both visual illusion and discomfort have been assessed ...
Reversibility of IOP-induced retinal ganglion cell injury in mice
It is commonly believed that high eye pressure induced retinal ganglion cell injury is irreversible in glaucoma, however current studies suggest otherwise. This thesis developed a glaucoma model in mice to demonstrate that ...
The effect of aging on spatial visual process outside the fovea
Studies have repeatedly shown that physiological aging impacts contextual spatial vision in central vision. Some visual functions are different between foveal and non-foveal vision and we have limited understanding of ...
Local microvascular reactivity in the regulation of retinal blood flow
Although a well-regulated blood supply is important for healthy neural function, the mechanism by which this occurs is still disputed; some studies charge this physiological response solely to the muscular arterioles, ...
A structural and functional profile of high myopia as a function of eye size
The prevalence of myopia and its associated sight threatening pathology is anticipated to increase, making high myopia a global health concern, especially in our ageing population. Although pathological sequelae and visual ...
Origins of feature selectivity in the visual system of two mammalian species
Visual information is transmitted from the retina to the primary visual cortex (V1) through the lateral geniculate nucleus (LGN). At each stage along this visual pathway, the receptive field properties of neurons are ...
Investigating the functional influence of perceptual stabilisation mechanisms of small eye movements
Even when we stare intently at an object, our eyes are in constant motion due to small, involuntary eye movements. Despite this, we do not perceive a jittery world as the visual system is able to compensate for the motion ...
Characterising the ocular phenotype in a murine model of Alzheimer’s disease
This thesis shows that amyloid beta found in the brain is also present in the retina of a murine model of Alzheimer’s disease. By applying non-invasive retinal techniques, we show that neuronal structural and functional ...
Electrophysiological and behavioural studies of top-down mechanisms of attention
Most modern skills, like driving a car, playing video games or reading a book, are relatively recent occurrences in human history and have presumably no specific hard-wired neural pathways. Instead, they piggyback on neural ...